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Collectively, our findings suggest UBE2T serves as a promising prognostic factor for HCC (show FAM126A ELISA Kits) and functions as an oncogene (show RAB1A ELISA Kits). The newly identified miR (show MLXIP ELISA Kits)-543/UBE2T/p53 (show TP53 ELISA Kits) axis may represent a new potential therapeutic target for HCC (show FAM126A ELISA Kits) intervention.
report the identification of a new allosteric pocket on Ube2T through a fragment screening using biophysical methods. Several fragments binding to this site inhibit ubiquitin conjugation in vitro
Results showed that UBE2T was overexpressed in osteosarcoma tissues and cell lines. Moreover, UBE2T knockdown inhibited osteosarcoma cell proliferation, migration, and invasion.
UBE2T plays an important role in the tumorigenesis of gastric cancer and could act as a potential independent prognostic factor for cancer therapy.
Identify critical roles of UBE2T in prostate cancer development and progression.
we identified UBE2T as a bona fide FA gene (FANCT) that also may be a rare cancer susceptibility gene.
UBE2T is the primary E2 of the FA pathway required for FANCD2 (show FANCD2 ELISA Kits) and FANCI (show FANCI ELISA Kits) activation.
Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia (show PALB2 ELISA Kits)
hypoxic conditions down-regulate UBE2T expression which correlates with an increased sensitivity to crosslinking agents consistent with a defective Fanconi anemia (show PALB2 ELISA Kits) pathway
UBE2T is the ubiquitin-conjugating enzyme (E2 (show UBE2D4 ELISA Kits)) in the Fanconi anemia (show PALB2 ELISA Kits) pathway and has a self-inactivation mechanism that could be important for negative regulation of the Fanconi anemia (show PALB2 ELISA Kits) pathway.
Overexpression of UBE2T in NIH3T3 cells significantly promoted colony formation in mouse cell cultures.
The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006
ubiquitin-conjugating enzyme E2T (putative)
, ubiquitin carrier protein T
, ubiquitin-conjugating enzyme E2 T
, ubiquitin-protein ligase T
, ubiquitin-conjugating enzyme E2T
, similar to Ubiquitin-conjugating enzyme E2 T (Ubiquitin-protein ligase T) (Ubiquitin carrier protein T)
, RAD6 homolog B
, ubiquitin carrier protein B
, ubiquitin conjugating enzyme
, ubiquitin-conjugating enzyme E2 B
, ubiquitin-conjugating enzyme E2(14k)
, ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)
, ubiquitin-conjugating enzyme E2B, RAD6 homolog
, ubiquitin-conjugating enzyme E2B, RAD6 homology
, ubiquitin-protein ligase B
, HSPC150 protein similar to ubiquitin-conjugating enzyme
, cell proliferation-inducing gene 50 protein