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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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1 | ABIN681922 | IHC (fro) IHC (p) | HRP | Rabbit | IgG | AA 1611-1631 | Log in to see | Polyclonal | 0 | |
1 | ABIN681915 | IHC (fro) IHC (p) | Biotin | Rabbit | IgG | AA 1611-1631 | Log in to see | Polyclonal | 0 |
General |
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Antigen | Complement Component 3 (C3) Antibodies |
Epitope | AA 1611-1631 Alternatives |
Reactivity | Cow (Bovine), Human, Mouse (Murine), Rat (Rattus) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This C3 antibody is un-conjugated Alternatives |
Application |
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Alternatives
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2 references available |
Supplier | Log in to see |
Product Details anti-C3 AntibodyTarget Details C3 Application Details Handling References for anti-C3 antibody (ABIN681913) Images |
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Purification | Purified by Protein A. |
Immunogen | KLH conjugated synthetic peptide derived from human Complement C3 alpha chain |
Isotype | IgG |
Plasmids, Primers & others | |
Target Details C3Product Details anti-C3 Antibody Application Details Handling References for anti-C3 antibody (ABIN681913) Images back to top |
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Antigen | |
Alternative Name | Complement C3 (C3 Antibody Abstract) |
Background |
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:837664, PubMed:29953, PubMed:959512, PubMed:1432298, PubMed:15833747, PubMed:16333141, PubMed:1961575). Subcellular location: Secreted Synonyms: ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p, Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3 |
Gene ID | 718 |
UniProt | P01024 |
Pathways | Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling |
Application DetailsProduct Details anti-C3 Antibody Target Details C3 Handling References for anti-C3 antibody (ABIN681913) Images back to top |
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Application Notes |
IHC-P 1:100-500 IHC-F 1:100-500 IF(IHC-P) 1:50-200 IF(IHC-F) 1:50-200 |
Restrictions | For Research Use only |
HandlingProduct Details anti-C3 Antibody Target Details C3 Application Details References for anti-C3 antibody (ABIN681913) Images back to top |
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Format | Liquid |
Concentration | 1 μg/μL |
Buffer | Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide. |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only. |
Storage | -20 °C |
Storage Comment | Store at -20°C |
Expiry Date | 12 months |
References for anti-C3 antibody (ABIN681913)Product Details anti-C3 Antibody Target Details C3 Application Details Handling Images back to top |
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Product cited in: |
Zhuang, Han, Li, Kienhöfer, Lee, Shumyak, Meyerholz, Rosadzinski, Rosner, Chan, Xu, Segal, Sobel, Yang, Hoffmann, Reeves: "A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM." in: Arthritis & rheumatology (Hoboken, N.J.), Vol. 68, Issue 12, pp. 2917-2928, 2016 Method employed by authors: ELISA (ELISA) Further details: Sample: serum Trang, Hirai, Nabeta, Fuke, Yamaguchi: "Membranoproliferative glomerulonephritis in a calf with nephrotic syndrome." in: Journal of comparative pathology, Vol. 151, Issue 2-3, pp. 162-5, 2014 (Sample species: Cow (Bovine)). Further details: Sample: Kidney |
ImagesProduct Details anti-C3 Antibody Target Details C3 Application Details Handling References for anti-C3 antibody (ABIN681913) back to top |
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Supplier Images |