anti-Human C3 antibody for Immunohistochemistry (Frozen Sections)

Recommended C3 Antibody (supplied by: Log in to see )

Antigen
Complement Component 3 (C3) Antibodies
  • AHUS5
  • ARMD9
  • ASP
  • C3a
  • C3b
  • CPAMD1
  • AI255234
  • HSE-MSF
  • Plp
  • C3
  • C3-1
  • sb:cb26
  • si:dkey-76b14.4
  • wu:fi34b03
  • wu:fj86e11
  • C3d
  • asp
  • cpamd1
  • c3
  • complement C3
  • complement component 3
  • complement component c3a, duplicate 1
  • complement component 3 L homeolog
  • complement component C3
  • complement C3-like
  • C3
  • c3a.1
  • c3.L
  • LOC443475
  • c3
  • c3-1
  • LOC100060539
Epitope
AA 1611-1631
15
14
6
6
5
5
4
4
4
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
284
78
65
15
15
9
7
6
5
4
3
1
Host
Rabbit
160
131
95
27
14
7
Clonality
Polyclonal
Conjugate
This C3 antibody is un-conjugated
38
37
23
7
7
5
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
223
198
101
71
68
60
56
51
45
38
38
31
17
10
5
5
5
2
2
2
1
1
1
1
1
1
1
1
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Catalog No. ABIN681913
$ 318.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN317012 EIA FACS IHC (fro) WB Mouse IgG2b Log in to see 013III-1-16 3
1 ABIN784157 EIA IHC (fro) IHC (p) Sheep IgG Log in to see Polyclonal 0
1 ABIN568574 EIA ID IHC (fro) IF IP TRITC Goat IgG Log in to see Polyclonal 0
1 ABIN568570 DB EIA ID IHC (fro) IF IP WB Biotin Goat IgG Log in to see Polyclonal 0
1 ABIN568571 EIA ID IHC (fro) IF IP FITC Goat IgG Log in to see Polyclonal 0
1 ABIN568572 DB EIA ID IHC (fro) IF IP WB HRP Goat IgG Log in to see Polyclonal 0
1 ABIN181129 EIA FACS IHC (fro) Mouse IgG1 Log in to see 053A-514-3-1-4 2
1 ABIN601080 IHC IHC (fro) WB Mouse IgG1 Log in to see 0
1 ABIN181107 EIA FACS IHC (fro) WB Mouse IgG1 Log in to see 053A-1149-3-1-4 (1003) 2
1 ABIN181106 EIA FACS IHC (fro) WB Mouse IgG1 Log in to see 10-02A 1
1 ABIN111065 IHC (fro) WB Mouse IgG1 Log in to see H11 2
1 ABIN681922 IHC (fro) IHC (p) HRP Rabbit IgG AA 1611-1631 Log in to see Polyclonal 0
1 ABIN215710 IHC IHC (fro) WB Mouse IgG2b Log in to see H13 0
1 ABIN609442 ELISA IHC IHC (fro) IHC (p) Mouse IgG2a Log in to see BH6 0
1 ABIN345336 ICC IHC IHC (fro) WB Mouse IgG1 Log in to see H11 0
1 ABIN601082 ELISA FACS IHC IHC (fro) IHC (p) Mouse IgG1 Log in to see 0
1 ABIN5774054 IHC (fro) IHC (p) Rabbit N-Term Log in to see E28-P 0
1 ABIN601081 ELISA FACS IHC IHC (fro) IHC (p) WB Mouse IgG1 Log in to see 0
1 ABIN111064 EIA IHC (fro) WB Mouse IgG2b Log in to see H13 3
1 ABIN681915 IHC (fro) IHC (p) Biotin Rabbit IgG AA 1611-1631 Log in to see Polyclonal 0

General

Antigen Complement Component 3 (C3) Antibodies
Epitope AA 1611-1631
(15), (14), (6), (6), (5), (5), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(284), (78), (65), (15), (15), (9), (7), (6), (5), (4), (3), (1)
Host Rabbit
(160), (131), (95), (27), (14), (7)
Clonality
Polyclonal
Conjugate This C3 antibody is un-conjugated
(38), (37), (23), (7), (7), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1)
Application Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(223), (198), (101), (71), (68), (60), (56), (51), (45), (38), (38), (31), (17), (10), (5), (5), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 2 references available
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Product Details anti-C3 Antibody

Target Details C3 Application Details Handling References for anti-C3 antibody (ABIN681913) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Complement C3 alpha chain
Isotype IgG
Plasmids, Primers & others

Target Details C3

Product Details anti-C3 Antibody Application Details Handling References for anti-C3 antibody (ABIN681913) Images back to top
Antigen
Alternative Name Complement C3 (C3 Antibody Abstract)
Background

C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:837664, PubMed:29953, PubMed:959512, PubMed:1432298, PubMed:15833747, PubMed:16333141, PubMed:1961575).

Subcellular location: Secreted

Synonyms: ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p, Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3

Gene ID 718
UniProt P01024
Pathways Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling

Application Details

Product Details anti-C3 Antibody Target Details C3 Handling References for anti-C3 antibody (ABIN681913) Images back to top
Application Notes IHC-P 1:100-500
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-C3 Antibody Target Details C3 Application Details References for anti-C3 antibody (ABIN681913) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-C3 antibody (ABIN681913)

Product Details anti-C3 Antibody Target Details C3 Application Details Handling Images back to top
Product cited in:

Zhuang, Han, Li, Kienhöfer, Lee, Shumyak, Meyerholz, Rosadzinski, Rosner, Chan, Xu, Segal, Sobel, Yang, Hoffmann, Reeves: "A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM." in: Arthritis & rheumatology (Hoboken, N.J.), Vol. 68, Issue 12, pp. 2917-2928, 2016 Method employed by authors: ELISA (ELISA) Further details: Sample: serum

Trang, Hirai, Nabeta, Fuke, Yamaguchi: "Membranoproliferative glomerulonephritis in a calf with nephrotic syndrome." in: Journal of comparative pathology, Vol. 151, Issue 2-3, pp. 162-5, 2014 (Sample species: Cow (Bovine)). Further details: Sample: Kidney

Images

Product Details anti-C3 Antibody Target Details C3 Application Details Handling References for anti-C3 antibody (ABIN681913) back to top
Supplier Images
Immunofluorescence (IF) image for anti-Complement Component 3 (C3) (AA 1611-1631) antibody (ABIN681913) Formalin-fixed and paraffin embedded rat liver labeled with Anti-C3 Polyclonal Antibo...
Immunofluorescence (IF) image for anti-Complement Component 3 (C3) (AA 1611-1631) antibody (ABIN681913) Formalin-fixed and paraffin embedded mouse kidney labeled with Anti-C3 Polyclonal Ant...
ELISA image for anti-Complement Component 3 (C3) (AA 1611-1631) antibody (ABIN681913) Antigen: 0.2 µg/100 µL Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:...