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General |
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Antigen | Complement Decay-Accelerating Factor (CD55) Antibodies |
Reactivity | Pig (Porcine) Alternatives |
Host | Mouse Alternatives |
Clonality (Clone) | |
Conjugate | This CD55 antibody is un-conjugated Alternatives |
Application |
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Western Blotting (WB)
Alternatives
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Supplier | Log in to see |
Product Details anti-CD55 AntibodyTarget Details CD55 Application Details Handling Images |
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Specificity | The monoclonal antibody PD2 recognizes Pig complement decay accelerating factor (DAF), also designated as CD55. |
Purification | Purified |
Immunogen | Pig DAF-Ig fusion protein. |
Clone | PD2 |
Isotype | IgG1 |
Plasmids, Primers & others | |
Target Details CD55Product Details anti-CD55 Antibody Application Details Handling Images back to top |
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Antigen | |
Alternative Name | cd55,daf (CD55 Antibody Abstract) |
Background | Cells express on their surface several proteins which protect against complement attack, namely C receptor I (CR1), decay accelerating factor (DAF), membrane cofactor protein (MCP) and CD59. CR1, DAF and MCP regulate the activation pathways of complement by either accelerating decay of the C3 and C5 convertase (CR1, DAF), or acting as cofactors for the serine protease factor I, which cleaves and irreversibly inactivates C3b (CR1, MCP). Pig DAF (CD55) is a 45-52 kDa transmembrane protein that binds C3b and C4b to inhibit formation and half-life of the C3 convertases. DAF is broadly distributed among cells in contact with serum, including both haematopoietic and nonhaematopoietic cells. Although DAF does not have an essential role in controlling hemolysis of erythrocytes, it has an important role in regulation of the deposition of C3 on nucleated cells. Together with other complement regulators DAF protects self cells from autologous complementmediated injury. DAF cooperates with CD46 in circumventing autologous C3 deposition, while CD59 inhibits the pathway at the critical end-point. |
UniProt | P08174 |
Pathways | Complement System, Regulation of Leukocyte Mediated Immunity |
Application DetailsProduct Details anti-CD55 Antibody Target Details CD55 Handling Images back to top |
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Application Notes | Immuno Assays. Flow Cytometry (Ref.2). Western blot. Positive Control: Porcine platelet lysate. Typical starting working dilution: 1/50. |
Restrictions | For Research Use only |
HandlingProduct Details anti-CD55 Antibody Target Details CD55 Application Details Images back to top |
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Format | Liquid |
Buffer | Buffer System: PBS Stabilizers: 0.1 % BSA |
Storage | 4 °C |
Storage Comment | Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch. |
Expiry Date | 12 months |