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anti-Human Complement 4 Antibodies:
anti-Rat (Rattus) Complement 4 Antibodies:
anti-Mouse (Murine) Complement 4 Antibodies:
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Mouse (Murine) Monoclonal Complement 4 Primary Antibody for IHC (fro), WB - ABIN2191789
Paul, Pozdnyakova, Mitchell, Carroll: Anti-DNA autoreactivity in C4-deficient mice. in European journal of immunology 2002
Show all 2 Pubmed References
An elevated number of C4 genes was observed in Alzheimer's disease (AD) patients as compared with healthy controls. The presence of high C4A (show C4B Antibodies) and C4B (show C4B Antibodies) copy numbers in AD patients could explain the increased C4 protein expression observed in AD patients, thus highlighting a possible role for C4A (show C4B Antibodies) and C4B (show C4B Antibodies) copy number variations in the risk of developing AD.
This study shows that the C4c/C4 ratio seems to be a better diagnostic measure than total antigenic C4 alone. Our findings underline that screening with total antigenic C4 implies a risk of overlooking C1-INH-HAE patients.
In comparison with C4-intact patients, C4-deficient patients had a different clinical/serologic lupus-like phenotype and lacked the lupus interferon (show IFNA Antibodies) signature.
C4 copy number variations and deficiency of C4A (show C4B Antibodies) both play an important role in the risk and manifestations of systemic lupus erythematosus in East Asian and European populations
Complement C4A deficiency (gene copy number <=1) was identified as a risk factor in a case-control study of juvenile dermatomyositis, particularly when subjects concurrently carried the HLA-DRB1 (show HLA-DRB1 Antibodies)*0301 allele.
Solution Structures of Complement C2 and Its C4 Complexes Propose Pathway-specific Mechanisms for Control and Activation of the Complement Proconvertases.
Coronary atherosclerosis is distinguished by serum C4 complement up-regulation and ceruloplasmin (show CP Antibodies) down-regulation.
find strong statistical significance for association of increased copy number of C4A (show C4B Antibodies) (OR 0.81 (0.73; 0.89);P = 4.4 x 10(-5)), with the effect most pronounced in individuals over 78 years (OR 0.67 (0.55; 0.81)) and females
genetic polymorphism is associated with acute graft versus host disease in unrelated hematopoietic stem cell transplantation
C4A (show C4B Antibodies) and C4B (show C4B Antibodies) gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.
The C4A (show C4B Antibodies)-complete transcript is the main transcript under normal physiological conditions, while C4A (show C4B Antibodies)-AS is augmented when mastitis develops.
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
, C4A anaphylatoxin
, Rodgers form of C4
, acidic C4
, acidic complement C4
, complement C4-A
, complement C4
, complement component 4 (within H-2S)
, complement component 4, gene 1
, complement component 4B (Chido blood group)
, complement component 4B (Childo blood group)
, MHC-linked complement C4
, sex-limited protein