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There is a strong association between serum levels of PTX3, M-ficolin, and SPA with the severity of ischemic stroke. Clinically, such association may be considered to evaluate the severity of the ischemic stroke.
These results suggest that FCN1 is a molecular target of intravenous IVIG in KD patients. We propose that these peptides and a humanized monoclonal antibody against FCN1 could be useful in combination therapy with IVIG.
M-ficolin interacts with A. fumigatus through interaction with chitin and beta-1,3 glucan and thereby mediates complement activation and potentiates IL-8 secretion of A549 cells.
higher ficolin-1 levels were associated with brain ischemic lesions and vasospasm following subarachnoid hemorrhage.
in northeastern Brazilian children and adolescents, FCN1 rs1071583 SNP was correlated with earlier age of type 1 diabetes mellitus (T1D) diagnosis; the SNP combination rs2989727 and rs1071583 was involved with T1D protection
Ficolin-1 could provide an alternative receptor-mediated mechanism for enhancing Ebola Virus infection, thereby contributing to viral subversion of the host innate immune system.
systemic lupus erythematosus patients with high ficolin-1 plasma levels had an increased risk of end-stage renal disease; there was no significant association between ficolin-1 and ficolin-3 with lupus nephritis
Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 mug/ml, respectively, p < 0.0001). At 48 h, ficolin-1 was significantly higher
Data indicate differences in the plasma concentrations of collectin liver 1 and collectin kidney 1, M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls.
This study aims to investigate whether an association exists between the ficolins that are part of the lectin complement pathway and systemic lupus erythematosus.
the differential binding of ficolin-1 to lymphocyte subsets suggests ficolin-1 as a novel link between innate and adaptive immunity.
In patients with early rheumatoid arthritis, elevated plasma M-ficolin levels correlated with a high disease activity score at baseline and 1 year. A low M-ficolin level was the strongest predictor of remission and low disease activity.
Data show that a photodynamic therapy (PDT) dose-dependent upregulation of CRP gene, as well as of PTX3 and ficolin 1 genes in lung tumor A549 cells, and indicate critical role played by PI3K/Akt/AP-1 pathway.
These results demonstrate that ficolin-1 and PTX3 heterocomplex formation acts as a noninflammatory "find me and eat me" signal to sequester altered-host cells.
M-ficolin bound strongly to serotype 19B and 19C polysaccharides.
Study interlinks the genotype and phenotype relationship concerning polymorphisms in FCN1 and corresponding concentrations and biological functions of M-ficolin.
A genotype study of common promoter FCN1 single nucleotide polymorphisms (SNPs) finds evidence for opposite associations between different FCN1 haplotypes and clinical leprosy in Euro-Brazilians and Afro-Brazilians.
Two polymorphisms in the promoter region of FCN1 is associated with the expression and synthesis of ficolin-1 as well as associated with decreased survival in a cohort of patient with systemic inflammatory response syndrome and sepsis.
M-ficolin concentrations in cord blood are related to circulating phagocytes and to early-onset sepsis
In patients with haematological malignancy undergoing chemotherapy, those with high MASP-2 were less likely to develop severe infections.
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.
, collagen/fibrinogen domain-containing protein 1
, ficolin (collagen/fibrinogen domain-containing) 1
, ficolin B
, collagen/fibrinogen domain-containing protein 2
, ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)
, ficolin 2
, ficolin (collagen/fibrinogen domain containing) 1