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KLK15 may be able to cleave many ECM components, similar to several members of the KLK family. Thus the protease could potentially be linked to tumorigenesis by promoting metastasis via this mechanism.
Data provide insights into the localization and possible role of KLK15 in human physiology.
Pronounced correlations between KLK10 (show KLK10 Proteins)/KLK11 (show KLK11 Proteins) (rs = 0.647) and between KLK9 (show KLK9 Proteins)/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases
Variations in KLK15, but not KLK11 (show KLK11 Proteins) expression were significantly associated with prognosis in gastric cancer
Advanced pathologic stage was associated with significantly higher expression of KLK15 and PCA3 mRNAs.
KLK15 mRNA expression levels are a novel marker for the differential diagnosis of prostate cancer.
These findings suggest a role for KLK15 genetic variation in the etiology of prostate cancer among men of European ancestry.
Multivariate analysis identified dichotomised KLK15 expression, corrected for patient parameters age, preoperative prostate-specific antigen level, pathological tumour stage, Gleason score and surgical margins, as an prognostic factor for poor outcome.
KLK15 expression analysis could be employed as a valuable tool for the discrimination between benign prostatic hyperplasia and prostate cancer tissue specimens and as an unfavorable prognostic marker for prostate cancer.
Data show six non-synonymous amino acid or frame shift changes in the KLK3 (show KLKB1 Proteins) gene and three changes in each of the neighboring genes, KLK15 and KLK2 (show KLK2 Proteins).
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms.
, ACO protease
, kallikrein-like serine protease