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persistently upregulated KLK5 resulted in atopic dermatitis-like skin architecture and secretion of atopic dermatitis-related cytokines from keratinocytes in a PAR2 (show F2RL1 Proteins) independent manner
It may be considered that circulating kallikrein 5 is down-regulated in chronic spontaneous urticaria patients, however its potential role and the possible underlying mechanism are unknown.
Thus, these findings point to the involvement of KLK5 in the proteolytic activation and spread of seasonal influenza viruses in humans.
The results of the present study indicated that the mRNA and protein expression levels of KLK5 were significantly upregulated in CRC (show CALR Proteins) tissues and sera, and were associated with an advanced tumor stage.
the expression level of hK5 in tumor stromal cells is a promising biomarker for poor prognosis in TNBC.
This report demonstrates that concurrent loss of KLK5 and KLK7 (show KLK7 Proteins) associates with a poor clinical outcome in Oral Squamous-Cell Carcinoma and could therefore serve as prognostic marker in this disease.
Low KLK5 expression is associated with breast cancer.
KLK5 is an important contributor to the Netherton syndrome proteolytic cascade.
Data indicate that the KLK5 SNP rs268908 was associated with an increased risk of prostate cancer.
Kallikrein 5 and kallikrein 12 (show KLK12 Proteins) cleave human influenza hemagglutinins and activate thrombolytic zymogens.
Ablation of KLK5 is not sufficient to rescue the lethal effect of LEKTI-deficiency. Double deficiency of both KLK5 and KLK7 completely rescues Netherton Syndrome-like phenotype.
the pruritogenic action of KLK5 may be primarily mediated by PAR2 (show F2RL1 Proteins) receptors
findings illustrate the crucial role of protease regulation in skin homeostasis and inflammation, and establish KLK5 inhibition as a major therapeutic target for NS
The cloning and characteriazation of recombinant Klk5 is reported.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein.
, kallikrein-like protein 2
, stratum corneum tryptic enzyme
, Kallikrein 1 renal/pancreas/salivary