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Ablation of KLK7 is not sufficient to rescue the lethal effect of LEKTI-deficiency. Double deficiency of both KLK7 and KLK5 completely rescues Netherton Syndrome-like phenotype.
Higher hK7 expression is associated with cervical adenocarcinomas
Prolonged Klk7 neutralization provokes profound abnormalities in Klk7 function, due to pH-induced high serine protease (show F2 Proteins) activity that degrades lipid processing enzymes and corneodesmosomes proteins.
KLK7 is differentially expressed in lesional biopsy specimens from patients with atopic eczema relative to normal skin
impaired KLK7 secretion from lamellar granules and increased LEKTI expression could underlie the insufficient activation of KLK in atopic dermatitis.
Epigenetic regulation of KLK7 gene expression in pancreatic and cervical cancer cells
Korean X-linked ichthyosis (show LBR Proteins) patients exhibited unimpaired skin barrier function and frequent association with the KLK7 gene polymorphism, which may differentiate them from Western X-linked ichthyosis (show LBR Proteins) patients.
This report demonstrates that concurrent loss of KLK5 (show KLK5 Proteins) and KLK7 associates with a poor clinical outcome in Squamous-Cell Carcinoma and could therefore serve as prognostic marker in this disease.
Data demonstrate that elevated levels of KLK6, KLK7 and KLK9 proteins are associated with poor glioblastoma patients survival.
Our findings suggest that serum KLK7 may be a valuable diagnostic biomarker for cervical cancer, and may help to determine the individual prognosis of these patients.
KLK6 (show KLK1 Proteins) and KLK7 mRNA and protein overexpression is directly associated with early-stage ovarian tumors.
Proteolytic cleavage of midkine (show MDK Proteins), CYR61 (show CYR61 Proteins), and tenascin-C (show TNC Proteins) govern the pathophysiological roles of KLK7.
Early-stage oral squamous cell carcinoma and high KLK7 mRNA levels were correlated with the rs10581213(wt/ins + ins/ins (show INS Proteins)) genotypes
This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19.
kallikrein 7 (chymotryptic, stratum corneum)
, protease, serine, 6
, serine protease 6
, stratum corneum chymotryptic enzyme
, kallikrein related-peptidase 7 (chymotryptic, stratum corneum)
, signal protein