Get this product for free
Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
---|---|---|---|---|---|---|---|---|---|---|
1 | ABIN954322 | EIA WB | Biotin | Mouse | IgG1 | Log in to see | CaPro-20 | 3 | ||
1 | ABIN264058 | EIA WB | Mouse | IgG2a | Log in to see | BDI095 | 0 | |||
1 | ABIN5568046 | EIA RIA | Biotin | Rabbit | AA 328-622 | Log in to see | Polyclonal | 0 | ||
1 | ABIN5568043 | EIA RIA | Rabbit | AA 328-622 | Log in to see | Polyclonal | 0 | |||
1 | ABIN5586252 | EIA | Rabbit | Log in to see | Polyclonal | 0 | ||||
1 | ABIN264120 | EIA | Mouse | IgG1 | Log in to see | BDI905 | 0 | |||
1 | ABIN613351 | EIA RIA | Biotin | Rabbit | IgG | Log in to see | Polyclonal | 0 | ||
1 | ABIN613311 | EIA RIA | Biotin | Rabbit | IgG | Log in to see | Polyclonal | 0 | ||
1 | ABIN613785 | EIA RIA | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
1 | ABIN613825 | EIA RIA | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
1 | ABIN613309 | EIA RIA | Biotin | Rabbit | IgG | Log in to see | Polyclonal | 0 | ||
1 | ABIN613783 | EIA RIA | Rabbit | IgG | Log in to see | Polyclonal | 0 |
General |
|
---|---|
Antigen | Coagulation Factor II (thrombin) (F2) Antibodies |
Reactivity | Human Alternatives |
Host | Mouse Alternatives |
Clonality (Clone) | |
Conjugate | This Prothrombin antibody is un-conjugated Alternatives |
Application |
Enzyme Immunoassay (EIA), Western Blotting (WB)
Alternatives
|
![]() |
3 references available |
Supplier | Log in to see |
Product Details anti-Prothrombin AntibodyTarget Details Prothrombin Application Details Handling References for anti-Prothrombin antibody (ABIN954323) Images |
|
Specificity | This antibody is specific for Human Prothrombin (CaPro-20). |
Cross-Reactivity (Details) | Species reactivity (tested):Human. |
Purification | Protein G Chromatography of Ascitic fluid. |
Immunogen | Human Prothrombin (CaPro-20) purified from plasma. |
Clone | CaPro-20 |
Isotype | IgG1 |
Target Details ProthrombinProduct Details anti-Prothrombin Antibody Application Details Handling References for anti-Prothrombin antibody (ABIN954323) Images back to top |
|
Antigen | |
Alternative Name | Prothrombin (F2) (F2 Antibody Abstract) |
Background | Prothrombin (Factor 2 in the coagulation cascade) is proteolytically cleaved at two sites by Factor Xa to form thrombin (Factor IIa) in an important step of the coagulation cascade which ultimately results in the stemming of blood loss. Thrombin being the single most important constituent of the coagulation cascade in terms of its feedback activation roles. Prothrombin also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in Prothrombin lead to various forms of thrombosis and dysprothrombinemia. Prothrombin is a 72 kDa blood clotting glycoprotein formed by and stored in the Liver. Prothrombin is present in the blood plasma and is converted to the key blood clotting agent thrombin, when blood vessels are damaged. Factor VII, another important haemostasis protein can be converted to VIIa by Factor IXa or Thrombin.Synonyms: Coagulation factor II |
Gene ID | 2147 |
NCBI Accession | NP_000497 |
UniProt | P00734 |
Pathways | Complement System, Peptide Hormone Metabolism, Regulation of G-Protein Coupled Receptor Protein Signaling |
Application DetailsProduct Details anti-Prothrombin Antibody Target Details Prothrombin Handling References for anti-Prothrombin antibody (ABIN954323) Images back to top |
|
Application Notes | Optimal working dilution should be determined by the investigator. |
Restrictions | For Research Use only |
HandlingProduct Details anti-Prothrombin Antibody Target Details Prothrombin Application Details References for anti-Prothrombin antibody (ABIN954323) Images back to top |
|
Concentration | 1.0 mg/mL |
Buffer | PBS containing 0.02 % Sodium Azide as preservative. |
Preservative | Sodium azide |
Precaution of Use | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handling Advice | Avoid repeated freezing and thawing. |
Storage | 4 °C/-20 °C |
Storage Comment | Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. |
References for anti-Prothrombin antibody (ABIN954323)Product Details anti-Prothrombin Antibody Target Details Prothrombin Application Details Handling Images back to top |
|
Background publications |
Bharadwaj, Iino, Kontoyianni, Smith, Foster, Kisiel: "Factor VII central. A novel mutation in the catalytic domain that reduces tissue factor binding, impairs activation by factor Xa, and abolishes amidolytic and coagulant activity." in: The Journal of biological chemistry, Vol. 271, Issue 48, pp. 30685-91, 1997 Kazama, Pastuszyn, Wildgoose, Hamamoto, Kisiel: "Isolation and characterization of proteolytic fragments of human factor VIIa which inhibit the tissue factor-enhanced amidolytic activity of factor VIIa." in: The Journal of biological chemistry, Vol. 268, Issue 22, pp. 16231-40, 1993 Yamamoto, Nakagaki, Kisiel: "Tissue factor-dependent autoactivation of human blood coagulation factor VII." in: The Journal of biological chemistry, Vol. 267, Issue 27, pp. 19089-94, 1992 |