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The downregulation of miR-199a contributes to paclitaxel (PTX) resistance in prostate cancer. YES1 mediates the regulation of miR-199a in prostate cancer PTX resistance.
findings identify acquired amplification of YES1 as a recurrent and targetable mechanism of resistance to EGFR (show EGFR Proteins) inhibition in EGFR (show EGFR Proteins)-mutant lung cancers and demonstrate the utility of transposon mutagenesis in discovering clinically relevant mechanisms of drug resistance.
Study on the role of miR (show MLXIP Proteins)-140-5p in inhibiting tumorigenesis in gastric cancer thru targeting YES proto-oncogene (show RAB1A Proteins) 1(YES1).
Our results suggest that H19 (show NCKAP1 Proteins) functions as a competitive endogenous RNA (ceRNA) by acting as a sink for miR-17-5p, revealing a potential ceRNA regulatory network involving H19 (show NCKAP1 Proteins) and miR-17-5p with a role in the modulation of YES1 expression
c-Yes plays an important role in migration and invasion of epithelial ovarian cancer.
Up-regulation of miR (show MLXIP Proteins)-210 inhibits hepatocellular carcinoma cell proliferation. Yes1 is a target of miR (show MLXIP Proteins)-210 and affects cell proliferation in HCC (show FAM126A Proteins).
findings indicate that miR (show MLXIP Proteins)-203 induces the apoptosis of KB cells by directly targeting Yes-1, suggesting its application in anti-cancer therapeutics
Results demonstrate a unique role for Yes in phosphorylation of FAK (show PTK2 Proteins) and in promoting PCa (show FLVCR1 Proteins) metastasis. Therefore, phosphorylated FAK (show PTK2 Proteins) Y861 and increased Yes expression may be predictive markers for PCa (show FLVCR1 Proteins) metastasis.
results indicated that miR-17-5p might play a role in human ovarian cancer by up-regulating YES1 expression.
Increased YES/SFK activation might serve as a clinical biomarker for predicting tumor resistance to IGF-1R (show IGF1R Proteins) inhibition.
investigated signaling pathways in early development by comparison of the phosphoproteome of wild type embryos with Fyn (show FYN Proteins)/Yes knockdown embryos that display specific convergence and extension cell movement defects
Ganglioside GD3 enhances invasiveness of gliomas by forming a complex with PDGFRalpha and Yes Kinase.
serum also activates TEAD-dependent transcription in a time- and dose-dependent manner and we identify Inter-alpha-inhibitor (IalphaI) as a component in serum capable of activating the Yes/YAP (show YAP1 Proteins)/TEAD pathway
Differentiation of embryonic stem cells is driven by c-Src (show SRC Proteins) is antagonized by c-Yes.
The antiapoptotic effect of YES1 activation in response to testicular heat insult may mediate via the regulation of extracellular signal-regulated kinase (ERK (show EPHB2 Proteins))/metastasis-associated 1 (MTA1 (show MTA1 Proteins)) cascade.
Results suggest that LKB1 (show STK11 Proteins) inactivation in the context of RAS activation facilitates metastasis by inducing an SFK-dependent expansion of a prometastatic, CD24 (show CD24 Proteins)(+) tumor subpopulation.
YAP (show YAP1 Proteins), TEAD2 (show TEAD2 Proteins) and Yes are highly expressed in self-renewing embryonic stem cells, and are activated by LIF (show LIF Proteins).
eIF4E (show EIF4E Proteins) and yes have cooperative roles in oncogenic transformation
Data show that in response to angiotensin II, the ability of ERK1/2 to remain within the cytoplasm or translocate into the nucleus is controlled by c-Src (show SRC Proteins)/Yes/Fyn (show FYN Proteins) or heterotrimeric G protein/PKCzeta (show PRKCZ Proteins) signaling, respectively.
Data imply that distinct modes of spatial activation and membrane delivery, under the control of specific acylation attachment sequences and endosome sub-type requirements, define distinct properties of the three SFKs (Src (show SRC Proteins) family kinases).
Binding of CD95 Ligand to CD95 on glioblastoma cells recruit Yes and the p85 subunit of phosphatidylinositol 3-kinase to CD95, which signal invasion via the glycogen synthase kinase 3-beta pathway and subsequent expression of matrix metalloproteinases.
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.
Yamaguchi sarcoma oncogene
, cellular yes-1 protein
, proto-oncogene c-Yes
, proto-oncogene tyrosine-protein kinase YES
, tyrosine-protein kinase Yes
, protein-tyrosine kinase
, tyrosine-protein kinase yes
, viral oncogene yes-1 homolog 1
, v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
, viral oncogene yes-1 homolog 1-like
, proto-oncogene tyrosine-protein kinase Yes-like
, proto-oncogene tyrosine-protein kinase Yes
, viral oncogene yes homolog
, c-yes proto-oncogene
, Yamagichi sarcoma viral (v-yes-1) oncogene homolog 1
, Yamaguchi sarcoma viral oncogene homolog 1