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This study assessed the relation of GLS2 downregulation in glioblastoma cells to its methylation and TP53 (show TP53 Proteins) status. Aberrant methylation of CpG islands, appear to contribute to silencing of GLS2 in glioblastoma cells by a mechanism bypassing TP53 (show TP53 Proteins) mutations.
Non-glutaminolysis function of GLS2 inhibits migration and invasion of hepatocellular carcinoma cells by repressing the epithelial-mesenchymal transition via the Dicer (show DICER1 Proteins)-miR (show MLXIP Proteins)-34a-Snail (show SNAI1 Proteins) axis.
observe that while miR (show MLXIP Proteins)-23 is capable of down-regulating the shortened KGA (show GLS Proteins) 3'UTR, it has only minor impact on the full-length KGA (show GLS Proteins) 3'UTR, demonstrating that additional potent negative regulation of GLS (show GLS Proteins) expression exists beyond this single microRNA targeting site
the crystal structure of full-length KGA (show GLS Proteins) and present a small-angle X-ray scattering model for full-length GLS2. These structures explain these proteins' compromised ability to assemble into catalytically active supra-tetrameric filaments, as previously shown for GAC (show GLS Proteins).
Cox (show COX8A Proteins) multivariate regression analysis demonstrated that DUOX1 (show DUOX1 Proteins), GLS2, FBP1 (show FBP1 Proteins) and age were independent risk factors for the prognosis of HCC (show FAM126A Proteins) patients after surgery
As a p53 target, GLS2 mediates p53's function in metastasis suppression through inhibiting Rac1.
IDO (show IDO1 Proteins), through GCN2 (show EIF2AK4 Proteins) kinase activation, downregulates the levels of TCRcomplex tchain and cMyc (show MYC Proteins), resulting in the suppression of Tcell proliferation and a reduction in the levels of LDHA (show LDHA Proteins) and GLS2
GABAergic neurons and astrocytes express Gls (show GLS Proteins) and Gls2 isoenzymes in nucleus and mitochondria, in addition to glutamatergic neurons
Phosphate-activated glutaminase and GAD65 (show GAD2 Proteins)/67 concentrations are compared in Alzheimer's disease cerebellum versus normal cerebellum controls
GLS2 expression is significantly decreased in hepatocellular carcinoma.
Gls2 expression is regulated by the dietary protein/carbohydrate ratio. This effect was not observed in Ppara (show PPARA Proteins)-null mice.
Study demonstrated expression of alternative transcripts of the mammalian Gls2 gene. Transcriptional mechanisms giving rise to GLS2 variants and isolation of novel GLS2 transcripts in human, rat and mouse are presented.
Phosphate-activated glutaminase (GLS2) is a p53 (show TP53 Proteins)-inducible regulator of glutamine (show GFPT1 Proteins) metabolism and reactive oxygen species
The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well. At least one transcribed pseudogene has been found for this gene.
, L-glutamine amidohydrolase
, breast cell glutaminase
, glutaminase I
, glutaminase liver isoform, mitochondrial
, phosphate-activated glutaminase
, phosphate-dependent glutaminase
, liver mitochondrial glutaminase