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Among the analysed polymorphisms, only the reduced folate carrier 1 (RFC1; SLC19A1) gene 80G>A polymorphism influenced the survival rate in primary liver cancers.
Cognition of adults aged from 55 to 90 was associated with MTHFR (show MTHFR Proteins), SLC19A1 gene polymorphism and serum homocysteine levels.
Polymorphisms and haplotypes of the SLC19A1 gene can be considered risk factors for idiopathic recurrent pregnancy loss.
results supported a role of the SLC19A1 gene in the etiology of Autism Spectrum Disorder, it was not a significant risk factor for the Autism Spectrum Disorder samples analyzed in this study.
We conclude that SLC46A1/PCFT (show SLC46A1 Proteins) and SLC19A1/RFC-1 are associated with DFS (show FST Proteins) of patients with colorectal cancer and hypothesize that poor response to 5-fluorouracil plus leucovorin therapy in some patients may be linked to low expression of these genes.
SLC19A1 expression was associated with increased risk of relapse or death, and SLC19A1 expression retained prognostic significance independent of age, disease stage and MYCN (show MYCN Proteins) amplification.
Our findings support the hypothesis that RFC1 (show RFC1 Proteins) A80G variant may contribute to non-syndromic cleft lip and palate susceptibility in a south Indian population.
the RFC-1 (show RFC1 Proteins) -43C>T, 80A>G, and 696T>C polymorphisms may be risk factors for ischemic stroke.
SLC19A1 rs1051266 GG/GA genotype is associated with first trimester fever.
SLC19A1 rs1051296 G>T, a miRNA binding site polymorphism, was associated with increased plasma methotrexate concentrations in Chinese children with acute lymphoblastic leukemia.
The mRNAs encoding Folr2 and the intestinal folate transporter Slc46a1 were not detected in 2-cel embryos and blastocysts.
Interleukin-6 (show IL6 Proteins) regulated the efficacy of methotrexate by decreasing the expression of SLC19A1.
First evidence of RFC expression in rapidly dividing cells of developing neural tube, craniofacial region, limb buds and heart duggests that these regions may be particularly susceptible to folate deficiency.
Inactivation of RFC1 (show RFC1 Proteins) impacts the expression of several ligands and interacting proteins in the cubilin (show CUBN Proteins)-amnionless (show AMN Proteins)-megalin (show LRP2 Proteins) complex that are involved in the maternal-fetal transport of folate and other nutrients.
Intestinal folate uptake process undergoes differentiation-dependent regulation and that this regulation is mediated via changes in the level of expression of both the RFC and PCFT (show SLC46A1 Proteins).
The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.
solute carrier family 19 (folate transporter), member 1
, folate transporter 1
, intestinal folate carrier 1
, placental folate transporter
, reduced folate carrier protein
, solute carrier family 19 member 1
, intestinal folate carrier protein
, reduced folate carrier 1
, solute carrier family 19 (sodium/hydrogen exchanger), member 1
, methotrexate carrier 1
, methotrexate carrier 2
, methotrexate carrier 5
, methotrexate carrier 6
, solute carrier family 19, member 1
, 58 kDa hydrophobic protein
, Folate carrier protein
, Methotrexate uptake protein
, Solute carrier family 19 member 1