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the G80A mutation in the RFC1 (show RFC1 Proteins) gene is associated with a greater risk for sporadic breast cancer and oxidative DNA damage
We demonstrated no difference in tHcy, folates, vitamin B12 (show NDUFB3 Proteins) levels and allelic frequencies of C677T and G80A polymorphisms in MTHFR (show MTHFR Proteins) and RFC (show RFC1 Proteins) genes between obese and no obese Tunisian children.
677T and 1298C alleles of MTHFR (show MTHFR Proteins) and G80 RFC-1 (show RFC1 Proteins) show association with hyperhomocysteinemia.
High RFC1 (show RFC1 Proteins) is associated with adenocarcinoma in non-small-cell lung carcinoma EGFR (show EGFR Proteins) [corrected] mutation.
Data suggest that genotypes for the MTHFR (show MTHFR Proteins) C677T and RFC (show RFC1 Proteins) rs1051266 polymorphism might be associated with the risk of conotruncal heart defects.
These data suggest a role of the polymorphism G80A in RFC1 (show RFC1 Proteins) in the risk of relapse and the mortality risk in patients with acute lymphoblastic leukemia.
The presence of the mutant MTHFR (show MTHFR Proteins) 1298C and also RFC (show RFC1 Proteins) 80A was linked to a decreased risk of developing chidlhood acute lymphoid leukemia (ALL).
The combined presence of RFC1 (show RFC1 Proteins) mutant alleles and the cystathionine b-synthase homozygous mutant allele was associated with a 4.81-fold increased risk of having a child with Down syndrome (95 % CI 1.82-12.68, P = 0.0007).
Maternal RFC-1 (show RFC1 Proteins) 80A>G polymorphism might be associated with an increased risk of having a birth with Down Syndrome. [Meta-analysis]
One-carbon genetic variants influence epigenetic of MHC2TA (show CIITA Proteins) and RFC1 (show RFC1 Proteins), thus contributing to phenotypic heterogeneity of systemic lupus erythematosus.
The mRNAs encoding Folr2 and the intestinal folate transporter Slc46a1 were not detected in 2-cel embryos and blastocysts.
Interleukin-6 (show IL6 Proteins) regulated the efficacy of methotrexate by decreasing the expression of SLC19A1.
First evidence of RFC expression in rapidly dividing cells of developing neural tube, craniofacial region, limb buds and heart duggests that these regions may be particularly susceptible to folate deficiency.
Inactivation of RFC1 (show RFC1 Proteins) impacts the expression of several ligands and interacting proteins in the cubilin (show CUBN Proteins)-amnionless (show AMN Proteins)-megalin (show LRP2 Proteins) complex that are involved in the maternal-fetal transport of folate and other nutrients.
Intestinal folate uptake process undergoes differentiation-dependent regulation and that this regulation is mediated via changes in the level of expression of both the RFC and PCFT (show SLC46A1 Proteins).
The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.
solute carrier family 19 (folate transporter), member 1
, folate transporter 1
, intestinal folate carrier 1
, placental folate transporter
, reduced folate carrier protein
, solute carrier family 19 member 1
, intestinal folate carrier protein
, reduced folate carrier 1
, solute carrier family 19 (sodium/hydrogen exchanger), member 1
, methotrexate carrier 1
, methotrexate carrier 2
, methotrexate carrier 5
, methotrexate carrier 6
, solute carrier family 19, member 1
, 58 kDa hydrophobic protein
, Folate carrier protein
, Methotrexate uptake protein
, Solute carrier family 19 member 1