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Results suggest that ASCT1 (show SLC1A4 Proteins)/2 may play an important role in regulating extracellular d-serine and NMDA receptor-mediated physiological effects and that ASCT1 (show SLC1A4 Proteins)/2 inhibitors have the potential for therapeutic benefit.
Our data confirm the heterogeneity of breast tumors at a functional proteomic level and dissects the relationship between metabolism-related proteins, pathological features and patient survival. These observations highlight the importance of SHMT2 (show SHMT2 Proteins) and ASCT2 as valuable individual prognostic markers and potential targets for personalized breast cancer therapy
ASCT2 was significantly overexpressed in the gastric cancer (GC) samples compared with adjacent non-cancerous gastric mucosa, in contrast, a significantly higher level of glutamine synthetase (GS (show GLUL Proteins)) expression was observed in normal tissues than in GC samples compared with adjacent non-cancerous gastric mucosa.
These results indicated that ASCT2 (SLC1A5) could be a novel therapeutic target against KRAS-mutant colorectal cancer.
AR signaling promoted glutamine (show GFPT1 Proteins) metabolism by increasing the expression of the glutamine (show GFPT1 Proteins) transporters SLC1A4 (show SLC1A4 Proteins) and SLC1A5, genes commonly overexpressed in prostate cancer. Correspondingly, gene expression signatures of AR activity correlated with SLC1A4 (show SLC1A4 Proteins) and SLC1A5 mRNA levels in clinical cohorts.
Results provide evidence that ASCT2 enhances glutamine uptake in glycolipid-enriched microdomain/rafts in GD2(+) small-cell lung cancer cells, leading to the enhancement of cell proliferation and migration.
High ASCT2 expression is associated with head and neck squamous cell carcinoma.
this study shows that IL-2 (show IL2 Proteins)-induced expression of SLC1A5 is a prerequisite for NKG2D (show KLRK1 Proteins)-mediated activation of NK cells
we found that PPARdelta (show PPARD Proteins) directly regulated neutral amino acid transporter (show SLC6A19 Proteins) SLC1 (show MCHR1 Proteins)-A5 (solute carrier family 1 member 5) and glucose transporter-1 (Glut1 (show SLC2A1 Proteins)) gene transcription, leading to uptake of glucose and amino acid, activation of mTOR (show FRAP1 Proteins) signaling, and tumor progression. In contrast, silence of PPARdelta (show PPARD Proteins) or its antagonist inhibited this event.
Data suggest that both heterogeneous nuclear ribonucleoprotein (show PCBP2 Proteins) type M (HNRPM (show HNRNPM Proteins)) and solute carrier (show SERTAD2 Proteins) 1A5 (SLC1A5) have role in the pathogenesis of ovarian cancer.
Data show that SERT (show SLC6A4 Proteins) associates with ASCT2 (alanine-serine-cysteine-threonine 2), a member of the solute carrier (show SERTAD2 Proteins) 1 family co-expressed with SERT (show SLC6A4 Proteins) in serotonergic neurons and involved in the transport of small neutral amino acids across the plasma membrane.
These findings highlight a mechanism of T cell activation involving ASCT2-dependent integration of the T cell receptor signal and a metabolic signaling pathway.
used as receptor by HERV-W Env (show ERVW-1 Proteins) glycoproteins when their sites for N-linked glycosylation are eliminated by mutagenesis
results strongly suggest that combinations of amino acid sequence changes and N-linked oligosaccharides in a critical carboxyl-terminal region of extracellular loop 2 (ECL2) control retroviral utilization of both the ASCT1 (show SLC1A4 Proteins) and ASCT2 receptors
amino acid transporter B(0)/ASC transporter 2 expression is necessary for SK-Hep cell growth
ASCT1 and ASCT2 mRNA were expressed in cultured blood-brain barrier[BBB] cells; expression of ASCT2 mRNA was 6.7-fold greater. ASCT2 is localized at the abluminal side of the mouse BBB, suggesting a key role in l-isomer-selective Asp transport at the BBB
data support ASCT2 function in both neuron and astrocyte cultures and identify a discrepancy between observed asc-1 (show SLC7A10 Proteins) immunoreactivity and lack of functional asc-1 (show SLC7A10 Proteins) activity in neuron cultures, elucidating processes that govern D-serine regulation
The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001
neutral amino acid transporter B(0)
, RD114 virus receptor
, RD114/simian type D retrovirus receptor
, baboon M7 virus receptor
, neutral amino acid transporter B
, sodium-dependent neutral amino acid transporter type 2
, solute carrier family 1 member 5
, alanine/serine/cysteine/threonine transporter 2
, neutral amino acid transporter B0
, ASC-like Na(+)-dependent neutral amino acid transporter ASCT2
, insulin-activated amino acid transporter
, solute carrier family 1, member 7
, CAZ-associated structural protein
, H4-system ASC-like transporter
, sodium-dependent neutral amino acid transporter ASCT2