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|Antigen||Minichromosome Maintenance Deficient 4 (MCM4) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This MCM4 antibody is conjugated to Alexa Fluor 488 Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
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Product Details anti-MCM4 AntibodyTarget Details MCM4 Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human MCM4|
Target Details MCM4Product Details anti-MCM4 Antibody Application Details Handling Images back to top
|Alternative Name||Mcm4/Cdc21 (MCM4 Antibody Abstract)|
The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3, which can be prevented by caspase inhibitors, results in the inactivation of the MCM complex (composed of at least MCM proteins 2-6) during apoptosis.
Synonyms: CDC21, CDC21 homolog, CDC54, DNA replication licensing factor MCM 4, DNA replication licensing factor MCM4, hCdc 21, hCdc21, Homolog of S. pombe cell devision cycle 21, KIAA4003, mcdc21, MCM 4, MCM 4 minichromosome maintenance deficient 4, MCM4, MCM4 minichromosome maintenance deficient 4, MCM4 minichromosome maintenance deficient 4, mitotin S. cerevisiae, MCM4_HUMAN, Mcmd4, MGC33310, Minichromosome Maintenance 4, Minichromosome maintenance complex component 4, Minichromosome maintenance deficient S. cerevisiae 4, Minichromosome maintenance deficient 4, Minichromosome maintenance deficient 4 homolog S. cerevisiae, Minichromosome maintenance, S. cerevisiae, homolog of, 4, mKIAA4003, P1 CDC21, P1-CDC21, P1CDC21, 19G antibody AI325074, AU045576, CDC 21, CDC 54.
|Pathways||DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA|
Application DetailsProduct Details anti-MCM4 Antibody Target Details MCM4 Handling Images back to top
|Application Notes||IF(IHC-P) 1:50-200|
|Restrictions||For Research Use only|
HandlingProduct Details anti-MCM4 Antibody Target Details MCM4 Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|