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Human MRE11A Protein expressed in Wheat germ - ABIN1311266
Lee, Padget, Curtis, Cowell, Moiani, Sondka, Morris, Jackson, Cockell, Tainer, Austin: MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA. in Biology open 2012
the essential role of Nbs1 (show NBN Proteins) is via its interaction with Mre11 and that most of the Nbs1 (show NBN Proteins) protein is dispensable for Mre11 complex functions and suggest that Mre11 and Rad50 (show RAD50 Proteins) directly activate ATM (show ATM Proteins).
Low MRE11 expression is associated with B-cell lymphomas.
cyclin A2 (show CCNA2 Proteins) controlled Mre11 abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 transcripts to mediate polysome loading and translation.
MRE11 complex influences the elimination of oocytes with unrepaired meiotic double-strand breaks post-natally, in addition to its previously described role in double-strand break repair and homologous synapsis during female meiosis.
Inhibiting MRE11 by mirin during meiotic maturation results in anaphase bridges and also increases the number of gammaH2AX (show H2AFX Proteins) foci in metaphase II. Compromised DNA integrity in mirin-treated oocytes indicates a role for MRE11 in chromosome integrity during meiotic maturation.
The authors demonstrate that ATM (show ATM Proteins) can be activated by DNA double-strand breaks in the absence of the Mre11-Rad50 (show RAD50 Proteins)-NBS1 (show NBN Proteins) (MRN) sensor complex.
TRIP13 (show TRIP13 Proteins)-deficient spermatocytes also progress to an H1t (show HIST1H1T Proteins)-positive stage if ATM (show ATM Proteins) activity is attenuated by hypomorphic mutations in Mre11 or Nbs1 (show NBN Proteins) or by elimination of the ATM (show ATM Proteins)-effector kinase CHK2 (show CHEK2 Proteins)
Impairment of Mre11 complex functions promotes the progression of mammary hyperplasias into invasive and metastatic breast cancers
results suggest that the MRE11-RAD50 (show RAD50 Proteins) complex plays important roles in recognition of dsDNA and initiation of STING-dependent signaling, in addition to its role in DNA-damage responses
The critical role of the MRE11 GAR motif in DSB repair is a mechanistic link between post-translational modifications at the MRE11 GAR motif and DSB processing, as well as the ATR/CHK1 (show CHEK1 Proteins) checkpoint signaling.
ATM (show ATM Proteins)-dependent phosphorylation of CtIP (show RBBP8 Proteins) and the epistatic and coordinated actions of MRE11 and CtIP (show RBBP8 Proteins) nuclease (show DCLRE1C Proteins) activities are required to limit the stable loading of Ku on single-ended DNA double-strand breaks.
These evidences suggest that NBS1 (show NBN Proteins) is regulated by two kind of mechanisms: complex formation dependent on ATM (show ATM Proteins), and protein degradation mediated by an unknown MG132-resistant pathway.
MRE11A gene polymorphism is associated with colorectal cancer.
Low MRE11 expression is associated with low-grade epithelial ovarian cancer.
although recruitment of the MRE11-RAD50 (show RAD50 Proteins)-NBS1 (show NBN Proteins) (MRN) DSB-sensing complex to viral genomes and activation of the ATM (show ATM Proteins) kinase can promote KSHV replication, proteins involved in nonhomologous end joining (NHEJ) repair restrict amplification of viral DNA.
Mre11-Rad50 (show RAD50 Proteins)-Nbs1 (show NBN Proteins) complex initiates DNA double strand break repair.
we show that Plk1 phosphorylates Mre11 at S649 during G2 DNA damage recovery and Mre11 phosphorylation at S649/S689 drives premature checkpoint termination and reduced DNA repair
In the absence of RAD51 (show RAD51 Proteins), the unprotected newly replicated genome is degraded by the exonuclease (show EXO1 Proteins) activity of MRE11, and the fragmented nascent DNA accumulates in the cytosol, initiating an innate immune response.
Both the genome instability and cell death of MRE11-null and MRE11-mutated H129N cells are significantly reversed by overexpression of Tdp2 (show TDP2 Proteins), an enzyme that eliminates covalent Top2 (show TOP2A Proteins) conjugates; thus, the essential role of Mre11 nuclease (show DCLRE1C Proteins) activity is likely to remove the DNA lesions.
The results illuminate the important role of Nbs1 (show NBN Proteins) and CtIP (show RBBP8 Proteins) in determining the substrates and consequences of human Mre11/Rad50 (show RAD50 Proteins) nuclease (show DCLRE1C Proteins) activities on protein-DNA lesions.
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog\; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
meiotic recombination 11 homolog A
, MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
, MRE11 homolog 1
, MRE11 homolog A
, double-strand break repair protein MRE11A
, meiotic recombination 11 homolog 1
, AT-like disease
, DNA recombination and repair protein
, endo/exonuclease Mre11
, meiotic recombination 11-like protein