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Low NEIL2 expression is associated with neoplasms.
Data indicate that DNA glycosylases MYH (show MUTYH Proteins), UNG2 (show CCNO Proteins), MPG (show MPG Proteins), NTH1, NEIL1 (show NEIL1 Proteins), 2 and 3 on nascent DNA.
The abnormal expressions of NEIL1 (show NEIL1 Proteins), NEIL2, and NEIL3 (show NEIL3 Proteins) are involved in cancer through their association with the somatic mutation load.
NEIL1 (show NEIL1 Proteins) and NEIL2 cooperate with TDG (show TDG Proteins) during base excision: TDG (show TDG Proteins) occupies the abasic site and is displaced by NEILs, which further process the baseless sugar, thereby stimulating TDG (show TDG Proteins)-substrate turnover.
Studied six SNP loci: (rs2279115 of BCL2 (show BCL2 Proteins) gene, rs804270 of NEIL2 gene, rs909253 of LTA (show LTA Proteins) gene, rs2294008 of PSCA (show PSCA Proteins) gene, rs3765524 and rs10509670 of PLCE1 (show PLCE1 Proteins) gene) to evaluate gastric cancer risk using magnetic nanoparticles and universal tagged arrays.
The variability of potentially important functional polymorphic variants of the IFNG (show IFNG Proteins), IFNGR2 (show IFNGR2 Proteins) and NEIL2 genes was characterized in representatives of four ethnic groups living in the Siberian region.
variant alleles in the NEIL2 (rs804270), APE1 (show APEX1 Proteins) (rs2275008), CYP2E1 (show CYP2E1 Proteins) (rs2031920) and MDM2 (show MDM2 Proteins) (rs2279744) SNPs may independently influence susceptibility to gastric cancer in a Northern Jiangsu Chinese population.
data strongly suggest that decreased repair of oxidative DNA base lesions due to an impaired NEIL2 expression in non-smokers exposed to SSS would lead to accumulation of mutations in genomic DNA of lung cells over time
CSB (show ERCC6 Proteins) protein stimulates NEIL2 DNA glycosylase activity
Results suggest that the decreased DNA repair capacity of the DNA glycosylase NEIL2 R257L variant can induce mutations that lead to lung cancer development.
NEIL2 plays an important role in long term genomic maintenance
the beta2/beta3 loop where Lys50 is located in NEIL2 is important for DNA binding, presumably lies next to a phosphate-binding site, and may represent a target for regulation of the enzyme activity.
NEIL1 (show NEIL1 Proteins) and NEIL2 are essential in the recognition of oxidized lesions arising from 8-oxoG and may play important roles in the repair of DNA damage induced by carcinogenic metals.
Recombinant human DNA Polymerase beta (show POLB Proteins) and recombinant mpise NEIL2 associated with microtubules in situ and in vivo.
Keap1 (show KEAP1 Proteins) recruits NEH2 through binding to ETGE and DLG (show DLG4 Proteins) motifs.
Results suggest a role for NEIL1 (show NEIL1 Proteins) and 2 as backup deoxyribo-5'-phosphate lyases in mammalian cells.
NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002
DNA glycosylase/AP lyase Neil2
, DNA-(apurinic or apyrimidinic site) lyase Neil2
, endonuclease 8-like 2
, endonuclease VIII-like 2
, nei homolog 2
, nei like 2
, nei-like protein 2
, Endonuclease VIII-like 2