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Low NEIL2 expression is associated with neoplasms.
Data indicate that DNA glycosylases MYH, UNG2, MPG, NTH1, NEIL1, 2 and 3 on nascent DNA.
The abnormal expressions of NEIL1, NEIL2, and NEIL3 are involved in cancer through their association with the somatic mutation load.
NEIL1 and NEIL2 cooperate with TDG during base excision: TDG occupies the abasic site and is displaced by NEILs, which further process the baseless sugar, thereby stimulating TDG-substrate turnover.
Studied six SNP loci: (rs2279115 of BCL2 gene, rs804270 of NEIL2 gene, rs909253 of LTA gene, rs2294008 of PSCA gene, rs3765524 and rs10509670 of PLCE1 gene) to evaluate gastric cancer risk using magnetic nanoparticles and universal tagged arrays.
The variability of potentially important functional polymorphic variants of the IFNG, IFNGR2 and NEIL2 genes was characterized in representatives of four ethnic groups living in the Siberian region.
variant alleles in the NEIL2 (rs804270), APE1 (rs2275008), CYP2E1 (rs2031920) and MDM2 (rs2279744) SNPs may independently influence susceptibility to gastric cancer in a Northern Jiangsu Chinese population.
data strongly suggest that decreased repair of oxidative DNA base lesions due to an impaired NEIL2 expression in non-smokers exposed to SSS would lead to accumulation of mutations in genomic DNA of lung cells over time
CSB protein stimulates NEIL2 DNA glycosylase activity
Results suggest that the decreased DNA repair capacity of the DNA glycosylase NEIL2 R257L variant can induce mutations that lead to lung cancer development.
the critical role of NEIL2 and PNKP in maintenance of the mammalian mitochondrial genome.
REG4, BIRC5 and NEIL2 genes might have a role in the sensitivity of cancer patients to radiotherapy
the beta2/beta3 loop where Lys50 is located in NEIL2 is important for DNA binding, presumably lies next to a phosphate-binding site, and may represent a target for regulation of the enzyme activity.
NEIL2 is involved in global genome repair mainly for removing oxidative products of cytosine.
NEIL1 and NEIL2 are preferentially involved in repair of lesions in DNA bubbles generated during transcription and/or replication
hNEIL2 recognized an apurinic/apyrimidinic site exclusively, and the activity for 5-hydroxyuracil and guanine-derived formamidopyrimidine was marginal
Reversible acetylation of Lys49 could thus regulate the repair activity of NEIL2 in vivo
the zinc finger motif in NEIL2 is essential for its structural integrity and enzyme activity
results show that the NEIL2-initiated repair of 5-hydroxyuracil (5-OHU) requires polynucleotide kinase (PNK)
A novel missense variant C367A and several other mutations were found in familial colorectal cancer DNA suggesting a limited role for this gene in the devlopment of CRC.
NEIL2 plays an important role in long term genomic maintenance
NEIL1 and NEIL2 are essential in the recognition of oxidized lesions arising from 8-oxoG and may play important roles in the repair of DNA damage induced by carcinogenic metals.
Recombinant human DNA Polymerase beta and recombinant mpise NEIL2 associated with microtubules in situ and in vivo.
Keap1 recruits NEH2 through binding to ETGE and DLG motifs.
Results suggest a role for NEIL1 and 2 as backup deoxyribo-5'-phosphate lyases in mammalian cells.
NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002
DNA glycosylase/AP lyase Neil2
, DNA-(apurinic or apyrimidinic site) lyase Neil2
, endonuclease 8-like 2
, endonuclease VIII-like 2
, nei homolog 2
, nei like 2
, nei-like protein 2
, Endonuclease VIII-like 2