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|Antigen||Ubiquitin Interaction Motif Containing 1 (UIMC1) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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|Specificity||This antibody reacts to Ubiquitin Interaction Motif Containing 1 (UIMC1/RAP80).|
Species reactivity (expected):Mouse.
Species reactivity (tested):Human.
|Immunogen||Synthetic peptide - KLH conjugated corresponding to a 17 amino acid from near the amino terminus of Human RAP80.|
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|Alternative Name||UIMC1 / RAP80 (UIMC1 Antibody Abstract)|
|Background||RAP80 is an ubiquitin binding protein containing 2 UIM (ubiquitin interacting motif) repeats. It is thought to recruit BRCA1 to DNA damage sites and work with BRCA1 in G2/M checkpoint control. RAP80 also interacts with retinoid-related testis-associated receptor and regulates estrogen receptor alpha. It can act as a transcriptional repressor and inhibits the interaction of NR6A1 with the corepressor NCOR1. At least four isoforms of RAP80 are known to exist.Synonyms: BRCA1-A complex subunit RAP80, RXRIP110, Receptor-associated protein 80, Retinoid X receptor-interacting protein 110, Ubiquitin interaction motif-containing protein 1|
|Pathways||DNA Damage Repair, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus|
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ELISA. Western blot: 1-2 μg/mL. Immunohistochemistry on Frozen Sections: 2.5 μg/mL. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
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|Buffer||PBS containing 0.02 % Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
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