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This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions\; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described.
LIM domain only 1 (rhombotin 1)
, LIM domain only protein 1
, LIM only 1
, T-cell translocation protein 1
, cysteine-rich protein TTG-1
, LIM domain only protein 3
, LIM domain only 3
, neuronal-specific transcription factor DAT1
, dopamine-inducible LIM-domain transcription factor DAT1
, T-cell translocation gene 1
, rhombotin 1