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homozygous missense mutation, p.Ile150Asn(c.449T>A), associated with permanent neonatal diabetes mellitus and neurological abnormalities
Data suggest that the first cases of MODY6 identified in Japan are result of missense (p.L157R, c.470T>G) or frameshift mutations (p.H206PfsTer38, c.616_617insC; p.P245RfsTer17, c.734delC; p.H206TfsTer56, c.616delC) in NEUROD1. The probands and affected family members exhibit intrinsically lower capacity of insulin secretion and neurological disorders. [CASE REPORT]
Data suggest the EGR1-miR-30a-5p-NEUROD1 axis might serve as a promising biomarker for diagnosis and treatment monitoring for schizophrenic patients in acute psychotic state. EGR1 and miR-30a-5p were remarkably downregulated, whereas NEUROD1 was significantly upregulated in PBMNCs from patients in acute psychotic state.
Mutation in NEUROD1 gene is associated with Maturity Onset Diabetes of the Young.
the importance of the oligomeric state of CtBP for coactivation of NeuroD1-dependent transcription, was investigated.
NeuroD1 seemed not sufficient to induce and maintain neuronal differentiation. Induction of neuronal differentiation by overexpression of Neurog1 initiated important steps for the development of glutamatergic neurons such as the spiral ganglion neurons
detected c.133A > G (p. Ala45Thr) in children with sensorineural hearing loss
Study reports a family with autosomal dominant diabetes related to a new NEUROD1 mutation, one of very few meeting Maturity Onset Diabetes of the Young criteria.
RNAi of lentiviral vector target NeuroD can reduce the migration and invasion abilities of PANC-1 cells
this study concludes that the novel mechanism would regulate the expression of ALK in neuroblastoma and that NeuroD1 should be significantly involved in neuroblastoma tumorigenesis.
NEUROD1 is important for maintenance of the retina function and partial loss-of-function mutation in NEUROD1 is likely a rare cause of nonsyndromic ARRP.
Increased expression of NeuroD1 subsequently leads to regulation of expression and function of the nicotinic acetylcholine receptor subunit cluster of alpha3, alpha5, and beta4.
Transactivation of Ctbp was dependent on the histone H3 lysine 9 (H3K9) demethylase activity of LSD1 facilitates subsequent H3K9 acetylation by the NeuroD1-associated histone acetyltransferase, P300/CBP-associated factor.
The variant A45T does not play a major role in the development of T2 Diabetes mellitus in East Asian descent.
Gene expression profiling revealed that permissive lines are typified by lower expression of the early neurogenic transcription factor ASCL1 and, conversely, by higher expression of the late neurogenic transcription factor NEUROD1.
NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM.
The overexpression of NeuroD may contribute to the tumorogenesis and development of pancreatic carcinoma, and is closely correlated to the cancer cell proliferation, p53 signal pathway and neural invasion.
Combined transfection of the three transcriptional factors, PDX-1, NeuroD1, and MafA, causes differentiation of bone marrow mesenchymal stem cells into insulin-producing cells
Photosensitive photoreceptor cells can be generated by combinations of transcription factors. The combination of CRX and RX generate immature photoreceptors: and additional NEUROD promotes maturation.
Most, if not all, nasal chemosensory neurons derive from NeuroD1-expressing globose basal cells of the immediate neuronal precursor variety.
Hbxip stimulated insulin enhancer activity by interacting with Pdx-1 and recruiting Neurod1 to Pdx-1.
that Gas1 is a direct target of NeuroD1 during the induction of the neurogenic program
miR-30a-5p ameliorates inflammatory responses and oxidative stress by targeting Neurod 1 through MAPK/ERK signalling
Retinoid acid (RA) and taurine further improved the differentiation efficiency of iPSCs overexpressing NeuroD1. However, RA and taurine did not promote differentiation in the absence of NeuroD1 overexpression.
Environmental enrichment enhances dorsal-ventral differences in DNA methylation, including at binding sites of the transcription factor NeuroD1, a regulator of adult neurogenesis.
ASCL1 and NEUROD1 distinguish heterogeneity in SCLC with distinct genomic landscapes.
The results of this study reveal essential roles for Neurod1 and Neurod6 in the survival of these neurons during development.
it is suggested that the suppression of NeuroD1 expression and the inhibition of NeuroD1/E-box interaction may play an important role in the Gc-mediated negative regulation of Pomc.
Wnt3a increased the expression of NeuroD1 and Ins2 in the hypothalamus.
The authors show that NeuroD1 directly binds regulatory elements of neuronal genes that are developmentally silenced by epigenetic mechanisms.
Expression of Transcription Factor NeuroD1 in Olfactory Bulb Glutamatergic Neurons
Data show that RNA binding protein HuD and special adenine-thymine (AT)-rich DNA-binding protein 1 (SATB1) form a positive regulatory loop that enhances NeuroD1 protein transcription and subsequent neuronal differentiation.
Neurod1 regulates the developments of opioid tolerance via a time-dependent pathway through contextual learning and a short-response pathway through antinociception.
The authors report the generation and characterization of Neurod1-CreER(T2) mouse lines and show that Neurod1 is not only expressed in immature newborn neurons of the adult hippocampus but also in fully mature granule cells of the dentate gyrus.
Study demonstrates a sequential expression order of NEUROD1>ISL1>POU4F1>POU4F2 during the inner ear neurogenesis.
In this study, we tried to establish an effective method of differentiation through the protein transduction of three transcription factors (Pdx1, NeuroD, and MafA) important to pancreatic beta cell development.
These data suggest that melatonin, by acting on MT1 receptors, affects NeuroD expression in the gastrointestinal tract and thus might contribute to circadian regulation in metabolic functions.
NeuroD-dependent neuronal death occurs through a Bax-dependent apoptotic pathway
This study demonistrated that NeuroD modulates opioid agonist-selective regulation of adult neurogenesis and contextual memory extinctionin mice.
Nkx2.2 must repress Neurod1 in a Pdx1+ pancreatic progenitor population to appropriately commit a subset of Neurog3+ endocrine progenitor cells to the alpha cell lineage.
Report pancreatic expression of NeuroD1 in pancreas.
NeuroD might be an essential regulatory factor for transcription of pig AgRP, playing a role in energy homeostasis regulation in the porcine and human brain.
Premature misexpression of NeuroD1 in chick partially recapitulates the amphibian condition by suppressing transit amplification.
NeuroD1 gene activity is turned on in new born neurons during post-metamorphic neurogenesis.
NeuroD promoter is substantially more sensitive to the phosphorylation status of Ngn2 than the Delta promoter, and that this can be attributed to differences in the ease of promoter activation.
This study reveals that the early larval stage in Xenopus (Stage 48) displays patterns of proliferation (NeuroD).
Data demonstrate that Neurogenin and NeuroD preferentially recognize neurogenesis-related targets through an enhancer signature of clustered consensus-binding sites and regulate neurogenesis by activating a core set of transcription factors.
The objective of this study was to identify polymorphisms in the functional and positional candidate gene NEUROD1 (neurogenic differentiation 1), and investigate their associations with production traits in reference families of Nelore cattle, seven single nucleotide polymorphisms (SNPs) in NEUROD1 were identified. Investigated marker effects on traits RFI, backfat thickness, ribeye area, body weight, metabolics
during embryonic development, NeuroD governs photoreceptor genesis via non-cell-autonomous mechanisms and that, during photoreceptor development and regeneration, Notch signaling is a mechanistic link between NeuroD and cell cycle exit.
differential levels of Neurod are required to generate endocrine pancreas subtypes from precursors during both embryonic and larval stages
Transcription factor neuroD, involved in retinogenesis, is co-opted by the circadian clock following photoreceptor differentiation.
Nkx2.2 coordinately activates NeuroD1 with Ngn3 in the endocrine progenitor cell and plays a role in the maintenance of NeuroD1 expression to regulate beta cell function in the mature islet.
The control of endocrine cell fate is instead fulfilled by two basic helix-loop-helix factors, Ascl1b and Neurod1 and NEUROG3 is not the unique pancreatic endocrine cell fate determinant in vertebrates.
the quantity, rather than quality (i.e., the ON/OFF states), of neurod expression directly or indirectly determines the two subtypes of posterior lateral line neurons
BrdU-, neuroD (nrd)- and Hu-studies reveal unusual non-ventricular neurogenesis in the postembryonic zebrafish forebrain.
in the zebrafish, two proneural genes are essential for differentiation of the hair cells, neuroD and atonal homolog 1
Coexpressed with cone-rod-homeobox transcription factor (Crx) in putative cone progenitors and nascent cone photoreceptors. In zebrafish retina, similar genetic cascades may regulate photoreceptor genesis and maturation.
NeuroD plays a fundamental role in photoreceptor genesis by regulating mechanisms that promote rod and cone progenitors to withdraw from the cell cycle.
This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus.
basic helix-loop-helix transcription factor
, beta-cell E-box transactivator 2
, class A basic helix-loop-helix protein 3
, neurogenic differentiation factor 1
, neurogenic helix-loop-helix protein NEUROD
, beta-cell E-box transcriptional activator 2
, basic helix-loop-helix factor 1
, neurogenic differentiation 1
, Beta-cell E-box transcriptional activator 2
, Neurogenic differentiation factor 1