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anti-Human Nkx2-2 Antibodies:
anti-Mouse (Murine) Nkx2-2 Antibodies:
anti-Rat (Rattus) Nkx2-2 Antibodies:
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Chicken Monoclonal Nkx2-2 Primary Antibody for BI, IHC (f) - ABIN2689863
Briscoe, Sussel, Serup, Hartigan-OConnor, Jessell, Rubenstein, Ericson: Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. in Nature 1999
Show all 5 Pubmed References
Human Polyclonal Nkx2-2 Primary Antibody for IHC, IHC (p) - ABIN4339979
Lawson, Cummings, Rassl, Russell, Brenton, Rintoul, Murphy: Two novel determinants of etoposide resistance in small cell lung cancer. in Cancer research 2011
Show all 3 Pubmed References
Human Monoclonal Nkx2-2 Primary Antibody for FACS, ELISA - ABIN969550
Wang, Gallego-Arteche, Iezza, Yuan, Matli, Choo, Zuraek, Gogia, Lynn, German, Bergsland, Donner, Warren, Nakakura: Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors. in Endocrine-related cancer 2009
Cow (Bovine) Polyclonal Nkx2-2 Primary Antibody for IHC, WB - ABIN2779575
Owen, Kowalewski, Lessnick: EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma. in PLoS ONE 2008
NKX2.2 demonstrated moderate or strong nuclear positivity in 91.2% of the tumors
nuclear import of Nkx2-2 is mediated not only by the classical import pathway but also directly by imp (show IMPA1 Antibodies) beta1 or imp 13 (show IPO13 Antibodies)
NKX2-2 positivity was defined as moderate-to-strong nuclear immunoreactivity in at least 5% of cells
Our study suggests that CGT (show UGT8 Antibodies) expression is controlled by balanced expression of the negative modulator OLIG2 (show OLIG2 Antibodies) and positive regulator Nkx2.2, providing new insights into how expression of GalCer is tightly regulated in cell-type- and stage-specific manners.
lentiviral overexpression of transcription factors ASCL1 (show ASCL1 Antibodies), SOX10 (show SOX10 Antibodies), and NKX2.2 in NPCs was sufficient to induce Sox10 (show SOX10 Antibodies) enhancer activity, OPC mRNA, and protein expression consistent with OPC fate
NKX2-2 and MNX1 (show MNX1 Antibodies) are etiological genes for neonatal diabetes.
NKX2.2 is a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
The NKX2-2 can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching.
NKX2-1 (show NKX2-1 Antibodies), NKX2-2, and MEF2C (show MEF2C Antibodies) define oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL).
Functional analysis revealed that NKX2.2 is an EWS (show EWSR1 Antibodies)/FLI (show FLII Antibodies)-regulated gene that is necessary for oncogenic transformation in Ewing's sarcoma.
The transient hypoxia at P7 altered the expression of Nkx2.2, resulting in delayed myelination in the external capsule.
This suggests that Nkx2.2 is not only required in the early pancreatic progenitors, but has additional essential activities within the endocrine progenitor population.
Lmx1a (show LMX1A Antibodies) is expressed in enterochromaffin cells and functions downstream of Nkx2.2.
nuclear import of Nkx2-2 is mediated not only by the classical import pathway but also directly by imp (show BRAP Antibodies) beta1 or imp 13 (show IPO13 Antibodies)
Demonstrate that a rare mature enteroendocrine cell subpopulation that is demarcated by Nkx2.2 expression display stem cell properties during normal intestinal epithelial homeostasis, but is not easily activated upon injury.
that Nkx2.2 and Nkx2.9 proteins play no role in the development of branchiovisceral motor neurons in hindbrain rostral to rhombomere 4.
These data identify Nkx2.2 as key regulator to determine neuronal subtypes in the p3 domain of the central nervous system.
The study demonstrates a previously unrecognized mechanism that controls insulin (show INS Antibodies) expression through c-Abl (show ABL1 Antibodies)-regulated NKx2.2 and GLUT2 (show SLC2A2 Antibodies).
Our studies reveal that a subset of mouse perineurial cells are CNS-derived, express Nkx2.2, and are essential for motor nerve development.
Nkx2.2 promotes timely specification and differentiation of myelinating oligodendrocyte lineage cells from species representing different vertebrate taxa.
Nkx2.2 coordinately activates NeuroD1 with Ngn3 in the endocrine progenitor cell and plays a role in the maintenance of NeuroD1 expression to regulate beta cell function in the mature islet.
The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.
NK2 transcription factor related, locus 2
, homeobox protein XENK-2
, NK-2 homolog B
, NK2 transcription factor-like protein B
, homeobox protein NK-2 homolog B
, homeobox protein Nkx-2.2
, Drosophila NK2 transcription factor related, locus 2
, glycoprotein GP330, renal
, homeobox protein Nkx2-2
, homeobox protein NK-2 homolog B-A
, homeobox protein Nkx-2.2a