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|Antigen||Epidermal Growth Factor Receptor (EGFR) Antibodies|
|Epitope||AA 25-346 Alternatives|
|Reactivity||Human, Rat (Rattus) Alternatives|
|Conjugate||This EGFR antibody is un-conjugated Alternatives|
Western Blotting (WB)
|4 references available|
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Product Details anti-EGFR AntibodyTarget Details EGFR Application Details Handling References for anti-EGFR antibody (ABIN3042517) Images
|Purpose||Rabbit IgG polyclonal antibody for Epidermal growth factor receptor(EGFR) detection. Tested with WB in Human,Rat.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for Epidermal growth factor receptor(EGFR) detection. Tested with WB in Human,Rat.
Gene Name: epidermal growth factor receptor
Protein Name: Epidermal growth factor receptor
|Purification||Immunogen affinity purified.|
|Immunogen||E.coli-derived human EGFR recombinant protein (Position: L25-K346). Human EGFR shares 89% amino acid (aa) sequence identity with mouse EGFR.|
Target Details EGFRProduct Details anti-EGFR Antibody Application Details Handling References for anti-EGFR antibody (ABIN3042517) Images back to top
|Alternative Name||EGFR (EGFR Antibody Abstract)|
The epidermal growth factor receptor (EGFR, ErbB-1, HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). EGFR exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha (TGFalpha). EGFR and its ligands are cell signaling molecules involved in diverse cellular functions, including cell proliferation, differentiation, motility, and survival, and in tissue development. Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer and glioblastoma multiforme. In this latter case a more or less specific mutation of EGFR, called EGFRvIII is often observed.
Synonyms: Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody|Avian erythroblastic leukemia viral (verbb) oncogene homolog antibody|Cell growth inhibiting protein 40 antibody|Cell proliferation inducing protein 61 antibody|EGF R antibody|EGFR antibody|EGFR_HUMAN antibody|Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) antibody|Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian) antibody|Epidermal growth factor receptor antibody|erbb 1 antibody|Erbb antibody|Erbb1 antibody|ERBB1 antibody|Errp antibody|HER1 antibody|mENA antibody|Oncogene ERBB antibody|PIG61 antibody|Proto-oncogene c-ErbB-1 antibody|Receptor tyrosine protein kinase ErbB 1 antibody|Receptor tyrosine protein kinase ErbB1 antibody|Receptor tyrosine-protein kinase ErbB-1 antibody|Urogastrone antibody|wa2 antibody|Wa5 antibody
|Pathways||NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation|
Application DetailsProduct Details anti-EGFR Antibody Target Details EGFR Handling References for anti-EGFR antibody (ABIN3042517) Images back to top
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
|Restrictions||For Research Use only|
HandlingProduct Details anti-EGFR Antibody Target Details EGFR Application Details References for anti-EGFR antibody (ABIN3042517) Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
References for anti-EGFR antibody (ABIN3042517)Product Details anti-EGFR Antibody Target Details EGFR Application Details Handling Images back to top
|Product cited in:||
Yue, Gao, Xue, Cui, Zhao, Yuan, Yin, Inagaki, Kokudo, Tang, Qu: "Des-?-carboxyl prothrombin induces matrix metalloproteinase activity in hepatocellular carcinoma cells by involving the ERK1/2 MAPK signalling pathway." in: European journal of cancer (Oxford, England : 1990), Vol. 47, Issue 7, pp. 1115-24, 2011
Gu, Zhang, Wu, Xu, Cui, Yang, Zhao, Sun: "Differential expression of decorin, EGFR and cyclin D1 during mammary gland carcinogenesis in TA2 mice with spontaneous breast cancer." in: Journal of experimental & clinical cancer research : CR, Vol. 29, pp. 6, 2010
Ge, Yu, Petitte, Zhang: "Epidermal growth factor-induced proliferation of chicken primordial germ cells: involvement of calcium/protein kinase C and NFKB1." in: Biology of reproduction, Vol. 80, Issue 3, pp. 528-36, 2009
Wang, Cheng, Cui, Zhong, Ward, Sun, Chen, Kokudo, Tang, Qu: "Des-gamma-carboxy prothrombin stimulates human vascular endothelial cell growth and migration." in: Clinical & experimental metastasis, Vol. 26, Issue 5, pp. 469-77, 2009
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