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We discovered a 0.6% frequency missense variant in ADCY7.
The stronger TNF-alpha responses in young males compared to females may be partly associated with male-specific down-regulation of ADCY7 and ADCY9.
The ADCY7 deficiency resulted in decreased cell growth, elevated apoptosis, and lower c-Myc expression in cultured leukemia cells obtained from acute myeloid leukemia patients.
evidence implicates ADCY7 in the modulation of mood regulatory neural mechanisms and, possibly, risk for and pathophysiology of depression.
we found that single nucleotide polymorphisms in ADCY7 associate with alcohol dependence in women, and these markers are also associated with ADCY7 expression (messenger RNA) levels.
construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase
The first cytoplasmic domain (residues 506-584) of adenylyl cyclase (AC) type VII is an internal regulatory subunit, interacting with a cardinal activator of AC (Gs alpha) and with the conserved first catalytic domain of type VII AC.
Brain type VII adenylyl cyclase isoform plays a sex-specific role in the manifestation of a heritable form of depressive symptoms in genetically modified mice.
AC7 is a specific downstream effector of the G(12/13) pathway
soluble adenylyl cyclase is responsive to both CO(2) and bicarbonate ion
Adenylyl cyclase 7 controls the extent of immune responses toward bacterial infection and is required for optimal functions of B and T cells during adaptive immune responses. It regulates cyclic adenosine monophosphate (cAMP) synthesis in B and T cells.
This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences.
adenylate cyclase 7
, adenylate cyclase type 7
, adenylyl cyclase 7
, ATP pyrophosphate-lyase 7
, adenylate cyclase type VII
, adenylyl cyclase type VII
, type 7 adenylyl cyclase
, adenylate cyclase type 7-like