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Our results suggest that dissociation between XB130 and Tks5 may facilitate lateral cell migration via XB130/Rac1, and vertical cell migration via Tks5/Cdc42 (show CDC42 Proteins). These molecular mechanisms will help our understanding of airway epithelial repair and regeneration.
these observations suggest that XB130 may be a novel molecular marker and potent therapeutic target for prostate
Results suggest that Tks5, similar to XB130, plays a role in cell proliferation and cell survival and that the interaction between XB130 and Tks5 appears to be critical for regulation of Src (show SRC Proteins)-mediated cellular homeostasis.
XB130 is a mediator for nicotine-derived nitrosamine ketone-induced cell migration through its translocation to cell motility related microfilamentous cellular structures.
XB130 could be useful as a prognostic marker of recurrence-free and overall survival in invasive ductal breast cancer, as well as for the response to chemotherapy.
This is the first study to reveal that XB130 overexpression may be related to the prediction of metastasis potency and poor prognosis for osteosarcoma patients
Results showed significant interaction between variants at TERF1 (show TERF1 Proteins) and AFAP1L2 loci. Given the key role of TERF1 (show TERF1 Proteins) in telomere biology and its physical interaction with AFAP1L2, these results support a role for telomere dysfunction in melanoma development.
High XB130 expression is associated with pancreatic ductal adenocarcinoma.
XB130 enhances cell motility and invasiveness by modulating the epithelial-mesenchymal transition-like process.
High nuclear expression of XB130 is associated with esophageal squamous cell carcinoma.
we showed that XB130 might play protective roles in lipopolysaccharide-induced systemic septic response and acute lung injury
May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation (By similarity).
AFAP1-like protein 2
, actin filament-associated protein 1-like 2
, phosphatidylinositol 3-kinase-associated protein