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Human FBLN3 Protein expressed in Wheat germ - ABIN1352379
Hu, Pioli, Siegel, Zhang, Nelson, Chaturbedi, Mathews, Ro, Alkafeef, Hsu, Hamamura, Yu, Hess, Tromberg, Linskey, Zhou: EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartment. in Molecular cancer 2011
Show all 2 Pubmed References
Human FBLN3 Protein expressed in HEK-293 Cells - ABIN2719970
Nandhu, Hu, Cole, Erdreich-Epstein, Rodriguez-Gil, Viapiano: Novel paracrine modulation of Notch-DLL4 signaling by fibulin-3 promotes angiogenesis in high-grade gliomas. in Cancer research 2014
Data suggest that HIF2alpha (show EPAS1 Proteins) mediates hypoxia-induced cancer growth/metastasis and that EFEMP1 is a downstream effector of hypoxia-induced HIF2alpha (show EPAS1 Proteins) during breast tumorigenesis.
EFEMP1 suppresses epithelial-mesenchymal transition and migration in endometrial carcinoma
Results indicate that fibulin-3 serves as a pro-invasive factor in bladder cancer, which may be mediated through modulation of IGFBP5 (show IGFBP5 Proteins) expression.
fibulin-3 confers a relatively high diagnostic efficacy and is acceptable to be an auxiliary biomarker to aid in malignant pleural mesothelioma identification.
FBLN-3 promoter region was highly methylated in some pancreatic cancer cell lines. FBLN-3 inhibited c-MET activation and expression and reduced cellular level of ALDH1 (show ALDH1A1 Proteins).
Serum EFEMP1 is down-regulated and involved in the progression of Prostate Cancer. It may serve as a useful diagnostic biomarker, with better diagnostic accuracy than PSA in Prostate Cancer.
SMRP (show ABCC5 Proteins) but not FBLN3 has a role in pleural effusions in in malignant pleural mesothelioma
EFEMP1 negatively modulates the migration ability in hepatocellular carcinoma. Reduction of EFEMP1 promotes the migration ability though increasing Matrix Metalloproteinase 2 (show MMP2 Proteins) and Matrix Metalloproteinase 9 (show MMP9 Proteins) expression via Extracellular Signal-Regulated MAP Kinase 1 (show MAPK3 Proteins)/2 activity.
The EFEMP1 rs3791679 polymorphism influences glioma susceptibility in the Chinese Han population.
Extensive methylation of the EFEMP1 gene promoter can discriminate invasive from benign IPMNs with superior accuracy owing to their stepwise accumulation of tumor progression
TWEAK (show TNFSF12 Proteins) promotes migration and invasion in murine embryonic fibroblasts through a mechanism dependent on ERKs activation and Fibulin 3 down-regulation.
Mutant fibulin-3 causes proteoglycan (show Vcan Proteins) accumulation, reduction of MMP-2 (show MMP2 Proteins) and MMP-9 (show MMP9 Proteins), but increase of TIMP-3 (show TIMP3 Proteins), and impairs diffusion across Bruch's membrane.
Define the Efemp1-p27(Kip1 (show CDKN1B Proteins)) axis as a potential marker module of PDAC cell sensitivity towards dual PI3K-mTOR (show FRAP1 Proteins) inhibitors.
The Efemp1 knock-in mice reconstitute the most important histopathologic symptoms of both Malattia leventinese and age-related macular degeneration.
fibulin-3 plays an important role in maintaining the integrity of fascia connective tissues and regulates aging.
both fibulin-3 and -5 are important in maintaining pelvic organ support in mice.
Data suggest a role for fibulin-3 in tissue maintenance and regeneration in the adult olfactory pathway.
This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.
EGF-containing fibulin-like extracellular matrix protein 1
, extracellular protein S1-5
, epidermal growth factor-containing fibulin-like extracellular matrix protein 1