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Human FBLN3 Protein expressed in Wheat germ - ABIN1352379
Hu, Pioli, Siegel, Zhang, Nelson, Chaturbedi, Mathews, Ro, Alkafeef, Hsu, Hamamura, Yu, Hess, Tromberg, Linskey, Zhou: EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartment. in Molecular cancer 2011
Show all 2 Pubmed References
Human FBLN3 Protein expressed in HEK-293 Cells - ABIN2719970
Nandhu, Hu, Cole, Erdreich-Epstein, Rodriguez-Gil, Viapiano: Novel paracrine modulation of Notch-DLL4 signaling by fibulin-3 promotes angiogenesis in high-grade gliomas. in Cancer research 2014
Fibulin-3 was upregulated in cervical carcinoma, and its overexpression was significantly related with malignant phenotype and poor prognosis of cervical carcinoma. Fibulin-3 promoted cervical cancer cell invasive capabilities by eliciting epithelial-mesenchymal transition and activating the PI3K-Akt-mTOR signal transduction pathway.
The EFEMP1, an extracellular matrix protein mutated in Doyne honeycomb retinal dystrophy, a genetic eye disease similar to AMD, and thrombospondin 1 (TSP1), an inhibitor of angiogenesis.
up-regulated in meningioma patients, decreased after surgery
During the anti-TNF therapy, the serum fibulin-3 level decreased in RA[rheumatoid arthritis] patients. Serum MRP8/14 concentration also decreased. No correlation between fibulin-3 and MRP8/14 was observed in the study group before and after the treatment. We found a poor correlation between serum fibulin-3 and other cartilage metabolism biomarkers after anti-TNF therapy.
Study findings indicate that EFEMP1 expression was significantly down-regulated in cellulite skin and decreased EFEMP1 expression in the dermis might contribute to the adipose tissue protrusion in cellulite, also known as 'fat herniation' due to less elastic fibrous septa that can no longer function as partition.
High fibulin-3 expression is associated with osteosarcoma invasion and metastasis by inducing epithelial to mesenchymal transition.
Immunohistochemistry demonstrated that EFEMP1 is expressed in cholangiocytes and vascular smooth muscle cells in liver specimens from patients with BA and other cholestatic diseases, but it is absent from cholangiocytes in normal control liver samples.
We presented a family with Doyne honeycomb retinal disease. Gene sequencing results revealed heterozygous mutations in EFEMP1 gene, which were consistent with the DHRD/ ML.
The extracellular matrix glycoprotein EFEMP1 is promising for future functional studies.
The results demonstrate the implication of Fibulin-3 in malignant mesothelioma due to fluoro-edenite exposure.
This study found a nominally different distribution of EFEMP1 genotypes, alleles and haplotypes between suicidal subjects and controls.
Glioma risks were higher in carriers of single-nucleotide polymorphisms (SNPs) rs1346787 and rs3791679 in EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) gene.
MiR-338-5p suppressed proliferation, migration and invasion of glioblastoma cells through inhibiting EFEMP1.
Results demonstrated that knockdown of EFEMP1 significantly inhibited ovarian cancer cell proliferation and induced cell cycle arrest at the G1/G0 phase.
this review and meta-analysis shows that fibulin-3 is a useful diagnostic marker for malignant pleural mesothelioma
Data suggest that HIF2alpha mediates hypoxia-induced cancer growth/metastasis and that EFEMP1 is a downstream effector of hypoxia-induced HIF2alpha during breast tumorigenesis.
EFEMP1 suppresses epithelial-mesenchymal transition and migration in endometrial carcinoma
Serum starvation of cultured retinal pigment epithelium cells changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of age-related macular degeneration.
Results indicate that fibulin-3 serves as a pro-invasive factor in bladder cancer, which may be mediated through modulation of IGFBP5 expression.
fibulin-3 confers a relatively high diagnostic efficacy and is acceptable to be an auxiliary biomarker to aid in malignant pleural mesothelioma identification.
TWEAK promotes migration and invasion in murine embryonic fibroblasts through a mechanism dependent on ERKs activation and Fibulin 3 down-regulation.
Mutant fibulin-3 causes proteoglycan accumulation, reduction of MMP-2 and MMP-9, but increase of TIMP-3, and impairs diffusion across Bruch's membrane.
Define the Efemp1-p27(Kip1) axis as a potential marker module of PDAC cell sensitivity towards dual PI3K-mTOR inhibitors.
The Efemp1 knock-in mice reconstitute the most important histopathologic symptoms of both Malattia leventinese and age-related macular degeneration.
fibulin-3 plays an important role in maintaining the integrity of fascia connective tissues and regulates aging.
both fibulin-3 and -5 are important in maintaining pelvic organ support in mice.
Data suggest a role for fibulin-3 in tissue maintenance and regeneration in the adult olfactory pathway.
This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.
EGF-containing fibulin-like extracellular matrix protein 1
, extracellular protein S1-5
, epidermal growth factor-containing fibulin-like extracellular matrix protein 1