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GRB7 gene expression in uterus during embryo implantation is regulated by Mmu-miR (show MLXIP Proteins)-193.
Findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR (show EGFR Proteins)-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy.
The adaptor Grb7 links netrin-1 (show NTN1 Proteins) signaling to regulation of mRNA translation of kappa opioid receptor (show OPRK1 Proteins).
Grb7 is identified as an integral component of stress granules.
Study provided a direct link between the signal adapter protein (show TOLLIP Proteins) Grb7, anti-apoptotic protein Hax1 (show HAX1 Proteins) isoform 1, and Caspase3-mediated apoptosis pathways, and suggests that besides modulating cell migration and signal transduction, Grb7 may also participate in Hax1 (show HAX1 Proteins)-related apoptosis pathways mediated by Caspase3.
Suggest close relationship between Grb7 gene amplification and GRB7 protein overexpression in human ovarian cancer. Immunohistochemistry might have limited diagnostic value in these tumors compared to fluorescence in situ hybridization.
Grb7 was found to be significantly related to the biological classification of breast cancer
apo (show C9orf3 Proteins) Grb7 SH2 domain crystallized in the trigonal space group P63 (show RPE65 Proteins), whereas the G7-B1-Grb7 SH2 domain complex crystallized in the monoclinic space group P21 (show CDKN1A Proteins)
The data reveal that Grb7 plays an important role in breast cancer progression, beyond the context of HER2 (show ERBB2 Proteins)+ve cell types
Grb7 protein interacts with Filamin-a, an actin-crosslinking component of the cell cytoskeleton.
Data suggest that calmodulin controls Grb7-mediated cell migration.
Data propose the phosphorylation state of Grb7-SH2 domain tyrosine residues could control Grb7 dimerization, and dimerization may be an important regulatory step in Grb7 binding to RTKs such as erbB2 (show ERBB2 Proteins).
GRB7 is a context-dependent oncogene (show RAB1A Proteins), which modulates the ERBB2 (show ERBB2 Proteins) signaling pathway through enhanced phosphorylation of ERBB2 (show ERBB2 Proteins) and Akt (show AKT1 Proteins).
propose that CaM inhibits the translocation of Grb7 to the nucleus after binding to its CaM-BD and therefore occluding its overlapping NLS (show ALDH1A2 Proteins)
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene.
growth factor receptor-bound protein 7
, growth factor receptor-bound protein 7-like
, GRB7 adapter protein
, Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7)
, epidermal growth factor receptor GRB-7
, growth factor receptor binding protein GRB7