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These findings suggest that SRA genetic variants may contribute to breast cancer risk
SRA1 was down expressed in HCC (show FAM126A ELISA Kits) and its level was associated with tumor size and GLU (show DCTN1 ELISA Kits) level in patients with HCC (show FAM126A ELISA Kits) for the first time. SRA1 may be a helpful biomarker to diagnostic HCC (show FAM126A ELISA Kits).
By studying a cohort of idiopathic hypogonadotropic hypogonadism, our findings strongly suggest that SRA1 gene function is required for initiation of puberty in humans
Results identified H15-H18 domains in SRA gene playing a key role in regulating ER-mediated transcription.
in human pluripotent stem cells SRA interacts with NANOG and is important for maintenance of the pluripotent state.
Data suggest that expression of SRA1 (mRNA and protein) is linked to cancer cell motility (invasiveness of breast/cervical tumor cells) and regulation of gene expression.
lncRNA SRA expression is potentially associated with PCOS and it has positive correlation with obesity in PCOS, thereby suggesting that elevated lncRNA SRA might be an important mediator in adiposity-related processes in PCOS for susceptible individuals.
In endometrioma patients, the surrounding ovarian tissue steroid receptor (show ESR2 ELISA Kits) RNA activator expression is higher compared to controls.
The structure is a five-helix bundle that is distinct from known RNA-binding motifs and instead is similar to the carboxy-terminal domain of the yeast spliceosome protein PRP18 (show PRPF18 ELISA Kits), which stabilizes specific protein-protein interactions.
This study provides evidence that both ER-beta1 and SRAP could be predictive biomarkers of tamoxifen benefit in ER-alpha (show ESR1 ELISA Kits)-negative premenopausal early breast cancer.
Visfatin (show NAMPT ELISA Kits) upregulated CD36 (show CD36 ELISA Kits) and SRA (show MSR1 ELISA Kits) expression and downregulated ABCA1 (show ABCA1 ELISA Kits) and ABCG1 (show ABCG1 ELISA Kits) expression, subsequently increased ox-LDL uptake and decreased cholesterol efflux, and finally promoted foam cell formation via the PI3K- and ERK (show EPHB2 ELISA Kits)-dependent pathways.
The results of this study demonstrated that SRA (show MSR1 ELISA Kits) could attenuate microglia mediated inflammation injury in ICH (show ACE ELISA Kits). In addition, SRA (show MSR1 ELISA Kits) mediated negative feedback mechanism in neuroimmune homeostasis.
these data are the first to indicate a functional role for SRA (show MSR1 ELISA Kits) in adipose tissue biology and glucose homeostasis in vivo.
Dax1 (show NR0B1 ELISA Kits) augmentation of LRH-1 (show NR5A2 ELISA Kits)-mediated Oct4 (show POU5F1 ELISA Kits) activation is dependent upon steroid receptor (show ESR2 ELISA Kits) RNA activator
DEAD-box RNA helicase (show DDX56 ELISA Kits) p68 (DDX5 (show DDX5 ELISA Kits)) and its associated noncoding RNA, steroid receptor (show ESR2 ELISA Kits) RNA activator (SRA (show MSR1 ELISA Kits)), form a complex with CTCF (show CTCF ELISA Kits) that is essential for insulator function
Steroid receptor (show ESR2 ELISA Kits) RNA activator stimulates proliferation as well as apoptosis in vivo
Results identify a pseudouridine synthase, mPus1p, as a coactivator for retinoic acid receptor (show RARA ELISA Kits) (mRAR)gamma when coexpressed with steroid receptor (show ESR2 ELISA Kits) RNA activator.
both MARCO (show MARCO ELISA Kits) and SR-A (show MSR1 ELISA Kits) could be involved in the positioning and differentiation of macrophages, possibly through interaction with endogenous ligands
These findings reveal novel functions of SRA (show MSR1 ELISA Kits) and Dax-1 (show NR0B1 ELISA Kits) in steroidogenesis and adrenal biology.
Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA.
steroid receptor RNA activator 1 (complexes with NCOA1)
, steroid receptor RNA activator protein
, steroid receptor coactivator
, steroid receptor RNA activator 1