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our findings demonstrated that lncRNA SRA is highly correlated with cancer progression and cervical cancer cell proliferation and migration. Furthermore, these results indicate that lncRNA SRA may be a potential therapeutic target and prognostic marker for cervical malignancy.
Surprisingly, Rac1 is not located at the binding site on the Sra1 subunit of the WAVE regulatory complex previously identified by mutagenesis and biochemical data. Rather, it binds to a distinct, conserved site on the opposite end of Sra1.
Steroid receptor RNA activator 1-small interfering RNA treatment significantly increased ER-alpha (show ESR1 Proteins) levels but reduced ER-beta (show ESR2 Proteins) levels in endometriotic stromal cells (ESCs (show NR2E3 Proteins)).
These findings suggest that SRA genetic variants may contribute to breast cancer risk
SRA1 was down expressed in HCC (show FAM126A Proteins) and its level was associated with tumor size and GLU (show DCTN1 Proteins) level in patients with HCC (show FAM126A Proteins) for the first time. SRA1 may be a helpful biomarker to diagnostic HCC (show FAM126A Proteins).
By studying a cohort of idiopathic hypogonadotropic hypogonadism, our findings strongly suggest that SRA1 gene function is required for initiation of puberty in humans
Results identified H15-H18 domains in SRA gene playing a key role in regulating ER-mediated transcription.
in human pluripotent stem cells SRA interacts with NANOG and is important for maintenance of the pluripotent state.
Data suggest that expression of SRA1 (mRNA and protein) is linked to cancer cell motility (invasiveness of breast/cervical tumor cells) and regulation of gene expression.
lncRNA SRA expression is potentially associated with PCOS and it has positive correlation with obesity in PCOS, thereby suggesting that elevated lncRNA SRA might be an important mediator in adiposity-related processes in PCOS for susceptible individuals.
Visfatin (show NAMPT Proteins) upregulated CD36 (show CD36 Proteins) and SRA (show MSR1 Proteins) expression and downregulated ABCA1 (show ABCA1 Proteins) and ABCG1 (show ABCG1 Proteins) expression, subsequently increased ox-LDL uptake and decreased cholesterol efflux, and finally promoted foam cell formation via the PI3K- and ERK (show EPHB2 Proteins)-dependent pathways.
The results of this study demonstrated that SRA (show MSR1 Proteins) could attenuate microglia mediated inflammation injury in ICH (show ACE Proteins). In addition, SRA (show MSR1 Proteins) mediated negative feedback mechanism in neuroimmune homeostasis.
these data are the first to indicate a functional role for SRA (show MSR1 Proteins) in adipose tissue biology and glucose homeostasis in vivo.
Dax1 (show NR0B1 Proteins) augmentation of LRH-1 (show NR5A2 Proteins)-mediated Oct4 (show POU5F1 Proteins) activation is dependent upon steroid receptor (show ESR2 Proteins) RNA activator
DEAD-box RNA helicase (show DDX56 Proteins) p68 (DDX5 (show DDX5 Proteins)) and its associated noncoding RNA, steroid receptor (show ESR2 Proteins) RNA activator (SRA (show MSR1 Proteins)), form a complex with CTCF (show CTCF Proteins) that is essential for insulator function
Steroid receptor (show ESR2 Proteins) RNA activator stimulates proliferation as well as apoptosis in vivo
Results identify a pseudouridine synthase, mPus1p, as a coactivator for retinoic acid receptor (show RARA Proteins) (mRAR)gamma when coexpressed with steroid receptor (show ESR2 Proteins) RNA activator.
both MARCO (show MARCO Proteins) and SR-A (show MSR1 Proteins) could be involved in the positioning and differentiation of macrophages, possibly through interaction with endogenous ligands
These findings reveal novel functions of SRA (show MSR1 Proteins) and Dax-1 (show NR0B1 Proteins) in steroidogenesis and adrenal biology.
Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA.
steroid receptor RNA activator 1 (complexes with NCOA1)
, steroid receptor RNA activator protein
, steroid receptor coactivator
, steroid receptor RNA activator 1