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Surprisingly, Rac1 is not located at the binding site on the Sra1 subunit of the WAVE regulatory complex previously identified by mutagenesis and biochemical data. Rather, it binds to a distinct, conserved site on the opposite end of Sra1.
Steroid receptor RNA activator 1-small interfering RNA treatment significantly increased ER-alpha (show ESR1 Proteins) levels but reduced ER-beta (show ESR2 Proteins) levels in endometriotic stromal cells (ESCs (show NR2E3 Proteins)).
These findings suggest that SRA genetic variants may contribute to breast cancer risk
The studies suggest that MNK (show ATP7A Proteins)-eiF4E (show EIF4E Proteins) axis controls the translation of specific mRNAs in cancer metastasis and neuronal synaptic plasticity by a novel mechanism involving the regulation of the translational repressor, CYFIP1 (show CYFIP1 Proteins). (Review)
rs4778298, a common variant at CYFIP1 (show CYFIP1 Proteins) is associated with inter-individual variation in surface area across the left supramarginal gyrus.
we show that stapled peptides targeting the interface between NCKAP1 (show NCKAP1 Proteins) and CYFIP1 (show CYFIP1 Proteins) destabilize the WASF3 (show WASF3 Proteins) complex... thereby suppressing invasion and metastasis of breast cancer cells.
SRA1 was down expressed in HCC (show FAM126A Proteins) and its level was associated with tumor size and GLU (show DCTN1 Proteins) level in patients with HCC (show FAM126A Proteins) for the first time. SRA1 may be a helpful biomarker to diagnostic HCC (show FAM126A Proteins).
By studying a cohort of idiopathic hypogonadotropic hypogonadism, our findings strongly suggest that SRA1 gene function is required for initiation of puberty in humans
Results identified H15-H18 domains in SRA gene playing a key role in regulating ER-mediated transcription.
Both mRNA and protein expression levels of Cyfip1 (show CYFIP1 Proteins) were significantly lower in ALL patients.
Visfatin (show NAMPT Proteins) upregulated CD36 (show CD36 Proteins) and SRA (show MSR1 Proteins) expression and downregulated ABCA1 (show ABCA1 Proteins) and ABCG1 (show ABCG1 Proteins) expression, subsequently increased ox-LDL uptake and decreased cholesterol efflux, and finally promoted foam cell formation via the PI3K- and ERK (show EPHB2 Proteins)-dependent pathways.
The results of this study demonstrated that SRA (show MSR1 Proteins) could attenuate microglia mediated inflammation injury in ICH (show ACE Proteins). In addition, SRA (show MSR1 Proteins) mediated negative feedback mechanism in neuroimmune homeostasis.
these data are the first to indicate a functional role for SRA (show MSR1 Proteins) in adipose tissue biology and glucose homeostasis in vivo.
Dax1 (show NR0B1 Proteins) augmentation of LRH-1 (show NR5A2 Proteins)-mediated Oct4 (show POU5F1 Proteins) activation is dependent upon steroid receptor (show ESR2 Proteins) RNA activator
DEAD-box RNA helicase (show DDX56 Proteins) p68 (DDX5 (show DDX5 Proteins)) and its associated noncoding RNA, steroid receptor (show ESR2 Proteins) RNA activator (SRA (show MSR1 Proteins)), form a complex with CTCF (show CTCF Proteins) that is essential for insulator function
Steroid receptor (show ESR2 Proteins) RNA activator stimulates proliferation as well as apoptosis in vivo
Results identify a pseudouridine synthase, mPus1p, as a coactivator for retinoic acid receptor (show RARA Proteins) (mRAR)gamma when coexpressed with steroid receptor (show ESR2 Proteins) RNA activator.
both MARCO (show MARCO Proteins) and SR-A (show MSR1 Proteins) could be involved in the positioning and differentiation of macrophages, possibly through interaction with endogenous ligands
These findings reveal novel functions of SRA (show MSR1 Proteins) and Dax-1 (show NR0B1 Proteins) in steroidogenesis and adrenal biology.
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.
steroid receptor RNA activator 1 (complexes with NCOA1)
, steroid receptor RNA activator protein
, steroid receptor coactivator
, steroid receptor RNA activator 1
, cytoplasmic FMR1-interacting protein 1
, cytoplasmic FMRP interacting protein 1
, selective hybridizing clone
, specifically Rac1-associated protein 1