Browse our anti-STAM (STAM) Antibodies

Caenorhabditis elegans (C. elegans) Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM) interaction partners

1. These data reveal that the STAM-Hrs complex, which down-regulates ligand-activated growth factor receptors from the cell surface of yeast and mammalian cells, also regulates the localization and signaling of a ciliary PC1 receptor-TRPP2 complex.[STAM]

Human Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM) interaction partners

1. The beta-arrestin1.STAM1 complex is necessary for promoting autophosphorylation of focal adhesion kinase (FAK). FAK is necessary for CXCL12-induced chemotaxis and associates with and localizes with beta-arrestin1 and STAM1 in a CXCL12-dependent manner.

2. The VHS domain of STAM1 directs AMSH to cleave longer Lys63-linked ubiquitin chains

3. Differential expression of the transcripts STAM connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.

4. ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation.

5. Overexpression of an AIP4 catalytically inactive mutant and a mutant that shows poor binding to STAM-1 fails to enhance CXCR4-induced ERK-1/2 signaling.

6. STAM proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway.

7. Interaction of TIMM8a with STAM1.

8. Data suggested that association with hepatocyte growth factor-regulated tyrosine kinase substrate is a prerequisite for STAM1 function in early endosome.

9. Hrs is a master molecule that controls in part the degradation of STAM1 and the accumulation of ubiquitinated proteins

10. Analysis with phospho-specific antibodies indicates that 3 kinases generate a signal-specific, combinatorial phosphorylation profile of the Hrs-STAM complex, with the potential of diversifying tyrosine kinase receptor signalling through a common element.

11. The cellular functions of UBPY are complex but clearly distinct from those of the Lys-63-ubiquitin-specific protease, AMSH, with which it shares a binding site on the SH3 domain of STAM

12. STAMs function prominently in endoplasmic reticulum-to-Golgi trafficking, most likely through direct interactions with the coat protein II complex

13. A novel ubiquitin binding site and the manner of ubiquitin recognition of the STAM1 VHS domain were proposed.

Mouse (Murine) Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM) interaction partners

1. the motor neuron-specific ISL1-LHX3 complex directly transactivates the Stam1 gene.

2. ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation.

3. These results demonstrate that the STAMs are indispensably involved in T-cell development and survival in the thymus through the prevention of apoptosis but are dispensable for the proximal signaling of TCR and cytokine receptors.

4. plays important role in the mammalian endosomal/vacuolar protein sorting pathway

5. Hrs is a master molecule that controls in part the degradation of STAM1 and the accumulation of ubiquitinated proteins