anti-Human STAM antibody for Immunohistochemistry

Recommended STAM Antibody (supplied by: Log in to see )

Antigen
Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM) Antibodies
  • STAM-1
  • STAM1
  • wu:fv75b10
  • zgc:55725
  • RGD1564499
  • signal transducing adaptor molecule
  • signal transducing adapter molecule 1
  • Signal transducing adapter molecule 1
  • signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
  • STAM
  • CpipJ_CPIJ003516
  • Tsp_03939
  • stam-1
  • Stam
  • stam
Epitope
Internal Region
10
10
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus), Mouse (Murine)
82
32
17
4
4
4
3
2
2
2
1
Host
Rabbit
61
23
1
Clonality
Polyclonal
Conjugate
This STAM antibody is un-conjugated
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
80
31
29
13
5
4
3
1
1
1
1
Options
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Catalog No. ABIN350877
$ 454.67
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
12.972757 ABIN2117564 ICC IHC WB Rabbit IgG AA 196-465 Log in to see Polyclonal 0
12.972757 ABIN3001495 IHC WB Rabbit IgG Log in to see Polyclonal 0
9.972757 ABIN2422753 IHC ELISA Rabbit IgG Log in to see Polyclonal 0
9.972757 ABIN2429349 IHC ELISA Rabbit IgG Log in to see Polyclonal 0
6.9727573 ABIN1938559 IHC IHC (p) WB Rabbit IgG AA 16-326 Log in to see Polyclonal 0
1 ABIN378275 IHC WB Rabbit IgG Internal Region Log in to see Polyclonal 0
1 ABIN378304 IHC WB Sheep IgG Internal Region Log in to see Polyclonal 0
1 ABIN1938562 IHC ELISA WB Alkaline Phosphatase (AP) Rabbit IgG AA 326-356 Log in to see Polyclonal 0
1 ABIN1938566 IHC ELISA WB PE Rabbit IgG AA 326-356 Log in to see Polyclonal 0
1 ABIN1938564 IHC ELISA WB Biotin Rabbit IgG AA 326-356 Log in to see Polyclonal 0
1 ABIN1938565 IHC ELISA WB FITC Rabbit IgG AA 326-356 Log in to see Polyclonal 0
1 ABIN1938563 IHC ELISA WB APC Rabbit IgG AA 326-356 Log in to see Polyclonal 0
1 ABIN1938567 IHC ELISA WB HRP Rabbit IgG AA 326-356 Log in to see Polyclonal 0
1 ABIN2572754 ELISA IHC WB Rabbit IgG AA 326-356 Log in to see Polyclonal 0
1 ABIN1841429 IHC IHC (p) WB Rabbit AA 326-356 Log in to see Polyclonal 0
1 ABIN2367241 IHC ELISA WB Rabbit IgG C-Term Log in to see Polyclonal 0
1 ABIN2367243 IHC ELISA WB APC Rabbit IgG C-Term Log in to see Polyclonal 0
1 ABIN2367245 IHC ELISA WB FITC Rabbit IgG C-Term Log in to see Polyclonal 0
1 ABIN2367246 IHC ELISA WB HRP Rabbit IgG C-Term Log in to see Polyclonal 0
1 ABIN2367247 IHC ELISA WB PE Rabbit IgG C-Term Log in to see Polyclonal 0

General

Antigen Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM) Antibodies
Epitope Internal Region
(10), (10), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity Human, Rat (Rattus), Mouse (Murine)
(82), (32), (17), (4), (4), (4), (3), (2), (2), (2), (1)
Host Rabbit
(61), (23), (1)
Clonality
Polyclonal
Conjugate This STAM antibody is un-conjugated
(3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(80), (31), (29), (13), (5), (4), (3), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-STAM Antibody

Target Details STAM Application Details Handling References for anti-STAM antibody (ABIN350877) Images
Specificity Specific for STAM1 & 2.
Purification Whole serum
Immunogen A synthetic peptide from the internal region of human STAM 1, 2 (STAM-1, STAM-2) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in many species including rat, mouse, zebra fish and xenopus.
Plasmids, Primers & others

Target Details STAM

Product Details anti-STAM Antibody Application Details Handling References for anti-STAM antibody (ABIN350877) Images back to top
Antigen
Alternative Name STAM (STAM Antibody Abstract)
Background STAM1:
Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a role in endocytic trafficking as well as in T-cell development.
Subunit: Heterodimer. Composed of STAM1 and HGS/HRS. Also interacts directly with STAMBP/AMSH.
Tissue specificity: Ubiquitously expressed. STAM2:
Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Probably acts via its association with ubiquitinated cargo proteins on the early endosome participates in their sorting for trafficking to the lysosome. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a in T-cell development.
Subunit: Heterodimer or heterotrimer. At least composed of STAM2 and HGS/Hrs. EPS15 can be part of the complex. Interacts directly with STAMBP/AMSH, JAK2 and JAK3. Also interacts with ubiquitinated proteins and the deubiquitinating enzyme USP8/UBPY. Interacts directly with CBX5 via the PxVxL motif. Interacts with VPS37C.
Tissue specificity: Ubiquitously expressed. Also known as: STAM1, STAM-1, STAM2, STAM-2, Signal transducing adapter molecule 1, Signal transducing adapter molecule 2, HBP, Hrs-binding protein.
Pathways EGFR Signaling Pathway, EGFR Downregulation

Application Details

Product Details anti-STAM Antibody Target Details STAM Handling References for anti-STAM antibody (ABIN350877) Images back to top
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only

Handling

Product Details anti-STAM Antibody Target Details STAM Application Details References for anti-STAM antibody (ABIN350877) Images back to top
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months

References for anti-STAM antibody (ABIN350877)

Product Details anti-STAM Antibody Target Details STAM Application Details Handling Images back to top
Background publications

Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006

Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, 2005

Steen, Kuster, Fernandez, Pandey, Mann: "Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway." in: The Journal of biological chemistry, Vol. 277, Issue 2, pp. 1031-9, 2002

Asao, Sasaki, Arita, Tanaka, Endo, Kasai, Takeshita, Endo, Fujita, Sugamura: "Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth." in: The Journal of biological chemistry, Vol. 272, Issue 52, pp. 32785-91, 1998

Takeshita, Arita, Asao, Tanaka, Higuchi, Kuroda, Kaneko, Munakata, Endo, Fujita, Sugamura: "Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM." in: Biochemical and biophysical research communications, Vol. 225, Issue 3, pp. 1035-9, 1996

Images

Product Details anti-STAM Antibody Target Details STAM Application Details Handling References for anti-STAM antibody (ABIN350877) back to top
Supplier Images
Western Blotting (WB) image for anti-Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 1 (STAM) (Internal Region) antibody (ABIN350877) WB on rat brain lysate using Rabbit pan antibody to an internal part of STAM 1, 2 (ST...