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The G-102A polymorphism in STAM2 is significantly associated with withers height, heart girth, cannon circumference, chest width, and hip height in Wuchuan Black cattle
SLBP (show SLBP ELISA Kits) is a potentially important cellular regulator of HIV-1, thereby establishing a link between histone metabolism, inflammation, and HIV-1 infection
showed that inhibiting the SLBP (show SLBP ELISA Kits) mRNA and protein levels were rescued by epigenetic modifiers suggesting that nickel's effects on SLBP (show SLBP ELISA Kits) may be mediated via epigenetic mechanisms
Cyclin F (show CCNF ELISA Kits)-mediated degradation of SLBP (show SLBP ELISA Kits) limits H2A.X (show H2AFX ELISA Kits) accumulation and apoptosis upon genotoxic stress in G2 cell cycle checkpoint.
CRL4(WDR23 (show DCAF11 ELISA Kits)) is required for efficient histone mRNA 3' end processing to produce mature histone mRNAs for translation. CRL4(WDR23 (show DCAF11 ELISA Kits)) binds and ubiquitylates SLBP (show SLBP ELISA Kits) in vitro and in vivo, and this modification activates SLBP (show SLBP ELISA Kits) function in histone mRNA 3' end processing without affecting its protein levels.
FEM1 proteins are ancient regulators of Stem-Loop Binding Protein (show SLBP ELISA Kits).
CRL4-DCAF11 (show DCAF11 ELISA Kits) mediates the degradation of SLBP (show SLBP ELISA Kits) at the end of S phase and this degradation is essential for the viability of cells.
The authors propose a structural organization where the AMSH (show STAMBP ELISA Kits)-SH3 binding motif interacts with the STAM2-SH3 domain (show ITSN1 ELISA Kits) and contributes to the correct positioning of AMSH (show STAMBP ELISA Kits) prior to polyubiquitin (show UBB ELISA Kits) chains' cleavage.
The VHS domain of STAM2 directs AMSH to cleave longer Lys63-linked ubiquitin chains
homologous domain of human Bro1 (show HMGCR ELISA Kits) domain-containing proteins, Alix (show PDCD6IP ELISA Kits) and Brox, binds CHMP4B (show CHMP4A ELISA Kits) but not STAM2, despite their high structural similarity
arsenic, a carcinogenic metal, decreases cellular levels of SLBP (show SLBP ELISA Kits) by inducing its proteasomal degradation and inhibiting SLBP (show SLBP ELISA Kits) transcription via epigenetic mechanisms
Stam2 is expressed in the nervous tissue, heart, digestive and endocrine system during embryo development.
These results demonstrate that the STAMs are indispensably involved in T-cell development and survival in the thymus through the prevention of apoptosis but are dispensable for the proximal signaling of TCR and cytokine receptors.
STAM (show STAM ELISA Kits) proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway.
SH3 domains of STAM2 and Grb2 (show GRB2 ELISA Kits) retain the moderate characteristics of recognizing their ligand proteins like other SH3 domains for signal protein (show KLK7 ELISA Kits) binding
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.
, Hrs-binding protein
, STAM-like protein containing SH3 and ITAM domains 2
, signal transducing adapter molecule 2
, Hrs binding protein
, hrs-binding protein
, signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
, EAST protein
, epidermal growth factor receptor-associated protein with SH3 and TAM domain
, signal transducing adaptor molecule 2
, signal transducing adapter molecule 2-like