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|Antigen||Teratocarcinoma-Derived Growth Factor 1 (TDGF1) Antibodies|
ELISA, Western Blotting (WB)
|3 references available|
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|Immunogen||Purified recombinant fragment of TEC expressed in E. Coli.|
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|Alternative Name||TDGF1 (TDGF1 Antibody Abstract)|
TEC, it belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.
Synonyms: CR, CRGF, CRIPTO, TDGF1
|Pathways||EGFR Signaling Pathway|
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Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
|Restrictions||For Research Use only|
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|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
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van Dijk, van Den Akker, Amelsvoort, Mano, Löwenberg, von Lindern: "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells." in: Blood, Vol. 96, Issue 10, pp. 3406-13, 2000
Kitanaka, Mano, Conley, Campana: "Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells." in: Blood, Vol. 91, Issue 3, pp. 940-8, 1998
|Product cited in:||
Yang, Ghiotto, Barbarat, Olive: "The role of Tec protein-tyrosine kinase in T cell signaling." in: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 607-17, 1999