anti-Mouse (Murine) Teratocarcinoma-Derived Growth Factor 1 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended Teratocarcinoma-Derived Growth Factor 1 Antibody (supplied by: Log in to see )

Antigen
Teratocarcinoma-Derived Growth Factor 1 (TDGF1) Antibodies
  • CR
  • CRGF
  • CRIPTO
  • CR1
  • cripto
  • cb85
  • tdgf1
  • wu:fe01d04
  • zgc:109829
  • Cripto-1
  • cr1
  • cr1a
  • frl-1
  • frl1
  • xcr1
  • TDGF1
  • tdgf3
  • cripto-3
  • teratocarcinoma-derived growth factor 1
  • teratocarcinoma-derived growth factor 1, member 3 L homeolog
  • teratocarcinoma-derived growth factor 1, member 1
  • TDGF1
  • Tdgf1
  • tdgf1
  • tdgf1.3.L
  • tdgf1.1
Epitope
Internal Region
34
17
14
14
14
8
7
4
3
2
2
2
1
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
193
81
52
1
1
Host
Goat
141
44
25
13
Clonality
Polyclonal
Conjugate
Un-conjugated
18
18
17
9
8
8
8
5
5
5
5
4
4
4
4
4
4
4
4
3
3
3
3
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
106
81
62
52
37
24
23
16
4
2
2
1
1
1
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Catalog No. ABIN498045
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN677957 IHC (p) WB HRP Rabbit IgG Log in to see Polyclonal 0
1 ABIN731432 IHC (p) WB HRP Rabbit IgG Log in to see Polyclonal 0
1 ABIN677950 IHC (p) WB Biotin Rabbit IgG Log in to see Polyclonal 0
1 ABIN731425 IHC (p) WB Biotin Rabbit IgG Log in to see Polyclonal 0
1 ABIN677948 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN731423 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal 0

General

Antigen Teratocarcinoma-Derived Growth Factor 1 (TDGF1) Antibodies
Epitope Internal Region
(34), (17), (14), (14), (14), (8), (7), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(193), (81), (52), (1), (1)
Host Goat
(141), (44), (25), (13)
Clonality
Polyclonal
Conjugate Un-conjugated
(18), (18), (17), (9), (8), (8), (8), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(106), (81), (62), (52), (37), (24), (23), (16), (4), (2), (2), (1), (1), (1)
Pubmed 1 reference available
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Product details

Target Details Application Details Handling References Images
Sequence YGRNCEHDVR KEN
Specificity Recognizes CRIPTO
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Canine (Dog), Bovine.
Species reactivity (tested):Human.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
Immunogen Peptide with sequence from the internal region of the protein sequence according to NP_003203.1. Genename: TDGF1

Target Details

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Antigen
Alternative Name TDGF1 / CRIPTO (TDGF1 Antibody Abstract)
Background Human Cripto-1 (CR-1), also known as Teratocarcinoma-derived growth factor 1 (TDGF1), is a member of the epidermal growth factor (EGF)-GFC family and has been implicated in both embryogenesis and carcinogenesis. During early vertebrate development, CR-1 functions as a co-receptor for Nodal, a transforming growth factor beta (TGFbeta) family member, and is essential for mesoderm and endoderm formation and anterior-posterior and left-right axis establishment. In adult tissues, CR-1 is expressed at a low level in all stages of mammary gland development, and expression increases during pregnancy and lactation. Over-expression of CR-1 in mouse mammary epithelial cells leads to their transformation in vitro, and when injected in mammary glands, CR-1 produces ductal hyperplasias.Synonyms: CRGF, Cripto-1 growth factor, Epidermal growth factor-like cripto protein CR1, Teratocarcinoma-derived growth factor 1
Gene ID 6997
NCBI Accession NP_003203
UniProt P13385
Pathways EGFR Signaling Pathway

Application Details

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Application Notes Peptide ELISA: Detection Limit: 1/128000. Western blot: Preliminary experiments in Human Umbilical Cord lysates and in lysates ofcell lines HEK293 and NIH3T3 gave no specific signal but low background (at antibodyconcentration up to 2 μg/mL). Immunohistochemistry: 3-5 μg/mLIn paraffin embedded Human Placenta shows stainng assocated with nuclei in sometrophoblasts and weak cytoplasm staining in cytotrophoblasts.
Restrictions For Research Use only

Handling

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Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.

References

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Background publications

Parisi, DAndrea, Lago, Adamson, Persico, Minchiotti: "Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells." in: The Journal of cell biology, Vol. 163, Issue 2, pp. 303-14, 2003

Images

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Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Teratocarcinoma-Derived Growth Factor 1 (TDGF1) (Internal Region) antibody (ABIN498045) Immunohistochemistry: CRIPTO Antibody staining of Paraffin Embedded ...