We are preparing the requested document. Please wait, this may take a while...!
|Antigen||Villin 1 (VIL1) Antibodies|
|Epitope||AA 1-209 Alternatives|
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
|Supplier||Log in to see|
Product detailsTarget Details Application Details Handling Images
|Purpose||Purified Mouse Monoclonal Antibody|
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50 % of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms. , ,.
Synonyms: Villin-1, VIL1, VIL
Immunogen: Purified recombinant fragment of human VIL1 (AA: 1-209) expressed in E. Coli.
Antigen Type: Recombinant Protein
Target DetailsProduct details Application Details Handling Images back to top
|Alternative Name||VIL1 (VIL1 Antibody Abstract)|
Other Names: Villin-1, VIL1, VIL
Description: This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed, they result from utilization of alternate poly-adenylation signals present in the terminal exon.
|Pathways||EGFR Signaling Pathway, Regulation of Actin Filament Polymerization|
Application DetailsProduct details Target Details Handling Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct details Target Details Application Details Images back to top
|Buffer||Purified antibody in PBS with 0.05 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
ImagesProduct details Target Details Application Details Handling back to top