anti-Rat (Rattus) Villin 1 antibody for Immunohistochemistry
Recommended Villin 1 Antibody (supplied by: Log in to see )
- Antigen
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Villin 1 (VIL1) Antibodies
show synonyms for this antigen- D2S1471
- VIL
- Vil
- vil1
- MGC64339
- VIL1
- vil1l
- zgc:55779
- villin 1
- villin 1 S homeolog
- VIL1
- Vil1
- vil1.S
- vil1
- Reactivity
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Human, Mouse (Murine), Rat (Rattus)
Alternatives - Host
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Rabbit
Alternatives - Clonality
- Conjugate
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Un-conjugated
Alternatives - Application
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ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
Alternatives - Supplier
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- Supplier Product No.
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| Relevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
|---|---|---|---|---|---|---|---|---|---|---|
| 4 | ABIN1876682 | IHC WB | Rabbit | IgG | Log in to see | Polyclonal | 0 |
General |
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|---|---|
| Antigen | Villin 1 (VIL1) Antibodies |
| Reactivity | Human, Mouse (Murine), Rat (Rattus) Alternatives |
| Host | Rabbit Alternatives |
| Clonality | |
| Conjugate | Un-conjugated Alternatives |
| Application |
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
Alternatives
|
| Supplier | Log in to see |
Product detailsTarget Details Application Details Handling Images |
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| Specificity | VIL1 Antibody detects endogenous levels of total VIL1 |
| Cross-Reactivity | Human, Mouse (Murine), Rat (Rattus) |
| Purification | The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific). |
| Immunogen | A synthesized peptide derived from human VIL1 |
| Isotype | IgG |
Target DetailsProduct details Application Details Handling Images back to top |
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| Antigen | |
| Alternative Name | VIL1 (VIL1 Antibody Abstract) |
| Background |
Description: Epithelial cell-specific Ca2+-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA), binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. Gene: VIL1 |
| Molecular Weight | 93kDa |
| Gene ID | 7429 |
| UniProt | P09327 |
| Pathways | EGFR Signaling Pathway, Regulation of Actin Filament Polymerization |
Application DetailsProduct details Target Details Handling Images back to top |
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| Application Notes | WB 1:500-1:2000 IHC 1:50-1:200 |
| Restrictions | For Research Use only |
HandlingProduct details Target Details Application Details Images back to top |
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| Format | Liquid |
| Concentration | 1 mg/mL |
| Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol. |
| Preservative | Sodium azide |
| Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
| Storage | -20 °C |
| Storage Comment | Store at -20 °C.Stable for 12 months from date of receipt |
| Expiry Date | 12 months |
ImagesProduct details Target Details Application Details Handling back to top |
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| Supplier Images |
Western blot analysis of Mouse liver tissue lysates, using VIL1 Antibody. The lane on...
ABIN6277617 at 1/100 staining Mouse kidney tissue by IHC-P. The sample was formaldehy...
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