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|Antigen||Cystathionase (Cystathionine gamma-Lyase) (CTH) Antibodies|
|Epitope||AA 112-131, Middle Region Alternatives|
|Reactivity||Human, Rat (Rattus) Alternatives|
|Conjugate||This CTH antibody is un-conjugated Alternatives|
Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
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Product Details anti-CTH AntibodyTarget Details CTH Application Details Handling References for anti-CTH antibody (ABIN3044240) Images
|Purpose||Rabbit IgG polyclonal antibody for Cystathionine gamma-lyase(CTH) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.|
Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
Rabbit IgG polyclonal antibody for Cystathionine gamma-lyase(CTH) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Gene Name: cystathionase(cystathionine gamma-lyase)
Protein Name: Cystathionine gamma-lyase
|Purification||Immunogen affinity purified.|
|Immunogen||A synthetic peptide corresponding to a sequence in the middle region of human Cystathionase(112-131aa DVYGGTNRYFRQVASEFGLK), different from the related rat and mouse sequences by two amino acids.|
|Plasmids, Primers & others|
Target Details CTHProduct Details anti-CTH Antibody Application Details Handling References for anti-CTH antibody (ABIN3044240) Images back to top
|Alternative Name||CTH (CTH Antibody Abstract)|
CTH(CYSTATHIONINE GAMMA-LYASE),also called CYSTATHIONASE, is an enzyme which breaks down cystathionine into cysteine and alpha-ketobutyrate.And the CTH gene is mapped on 1p31.1. In some bacteria and mammals, including humans, this enzyme takes part in generating hydrogen sulfide and that genetic deletion of this enzyme in mice markedly reduced H2S levels in the serum, heart, aorta, and other tissues. Mutant mice lacking CTH displayed pronounced hypertension and diminished endothelium-dependent vasorelaxation. Cystathionine was physiologically activated by calcium and calmodulin, which is a mechanism for H2S formation in response to vascular activation.
Synonyms: CGL_HUMAN antibody|CTH antibody|cystathionase(cystathionine gamma-lyase) antibody|Cystathionine gamma lyase antibody|Cystathionine gamma-lyase antibody|Cysteine desulfhydrase antibody|Gamma cystathionase antibody|Gamma-cystathionase antibody|Homoserine deaminase antibody|Homoserine dehydratase antibody|MGC9471 antibody
Application DetailsProduct Details anti-CTH Antibody Target Details CTH Handling References for anti-CTH antibody (ABIN3044240) Images back to top
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CTH Antibody Target Details CTH Application Details References for anti-CTH antibody (ABIN3044240) Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.|
|Preservative||Thimerosal (Merthiolate), Sodium azide|
|Precaution of Use||This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
|Expiry Date||12 months|
References for anti-CTH antibody (ABIN3044240)Product Details anti-CTH Antibody Target Details CTH Application Details Handling Images back to top
|Product cited in:||
Liu, Li, Liang, Li, Jiang, Chu, Yang: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, 2018
Qi, Zhao, Li, Shao, Wang, Sui, Yu, Shao, Gui, Li, Jia, Jiang, Li, Zhang, Wang, Wang: "High C-X-C motif chemokine 5 expression is associated with malignant phenotypes of prostate cancer cells via autocrine and paracrine pathways." in: International journal of oncology, Vol. 53, Issue 1, pp. 358-370, 2018
Shi, Guo, Shi, Yu, Song, Li: "Caffeic Acid Phenethyl Ester inhibit Hepatic Fibrosis by Nitric Oxide Synthase and Cystathionine Gamma-Lyase in Rats." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 21, pp. 2774-80, 2016
Chen, Wang, Li, Jiang, Lu, Zhou: "Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats." in: Journal of diabetes research, Vol. 2016, pp. 9726503, 2016
Guo, Duan, Wang, Zhou, Li, Sun: "Endogenous carbon monoxide downregulates hepatic cystathionine-γ-lyase in rats with liver cirrhosis." in: Experimental and therapeutic medicine, Vol. 10, Issue 6, pp. 2039-2046, 2015
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