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These results suggest that LWS-activating region (LAR (show PTPRF Proteins)) regulates both LWS-1 and LWS-2 by enhancing their expression and that interaction of LAR (show PTPRF Proteins) with the promoters is competitive between the two genes in a developmentally restricted manner.
CFP1 has an important role during postgastrulation development
Data indicate that CXXC finger protein 1 (Cfp1) is necessary for hematopoietic stem and multi-potential progenitor cell function and for the developmental potential of differentiating hematopoietic cells.
NF-kappaB (show NFKB1 Proteins) recruitment enhanced the occupancy of the CpG island within the 14-3-3gamma (show YWHAG Proteins) promoter by CFP1.14-3-3gamma induction in CSR (show SCARA3 Proteins) is enabled by the CFP1-mediated H3K4me3 enrichment in the promoter, dependent on NF-kappaB (show NFKB1 Proteins) and sustained by E2A (show TCF3 Proteins).
The results demonstrated that Cfp1 is a specificity factor that integrates multiple signals, including promoter CpG content and gene activity, to regulate genome-wide patterns of H3K4me3.
a primary function of non-methylated CpG islands is to genetically influence the local chromatin modification state by interaction with Cfp1 and perhaps other CpG-binding proteins
embryonic stem cells lacking Cfp1 (CXXC1(-/-)) are viable but show increased levels of global histone H3K4 methylation, suggesting that Cfp1 functions to inhibit or restrict the activity of the Setd1A histone H3K4 methyltransferase complex.
findings show that CGBP is essential for normal epigenetic modification of the genome by cytosine methylation and for cellular differentiation, consistent with the requirement for CGBP during early mammalian development
expression of either the amino half of Cfp1 (amino acids 1 to 367 [Cfp1(1-367)]) or the carboxyl half of Cfp1 (Cfp1(361-656)) is sufficient to correct all of the defects observed with embryonic stem cells that lack Cfp1
NF-kappaB (show NFKB1 Proteins) recruitment enhanced the occupancy of the CpG island within the 14-3-3gamma (show YWHAG Proteins) promoter by CFP1.14-3-3gamma induction in CSR is enabled by the CFP1-mediated H3K4me3 enrichment in the promoter, dependent on NF-kappaB (show NFKB1 Proteins) and sustained by E2A (show TCF3 Proteins).
The crescent (show SFRP5 Proteins)-shaped CFP1 CXXC domain is wedged into the major groove of the CpG DNA, distorting the B-form DNA, and interacts extensively with the major groove of the DNA.
CXXC finger protein 1 is a component of the mammalian Set1 histone H3 (show HIST3H3 Proteins)-Lys4 methyltransferase complex
CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB (show PLN Proteins)-985 myeloid cell line.
CGBP interacts with MLL1, MLL2 as well as Set1 H3-Lysine 4 (H3K4) specific methyl-transferases and plays critical roles in regulations of MLL (show MLL Proteins) target genes.
study shows endogenous DNMT1 (show DNMT1 Proteins) & CFP1 interact in vivo; CFP1 interaction with Setd1A or Setd1B not required for its interaction with DNMT1 (show DNMT1 Proteins); result indicates CFP1 intersects cytosine methylation machinery independently of its association with Setd1 complexes
Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression (Carlone and Skalnik, 2001
cpg binding protein
, CXXC finger protein 1
, cpG-binding protein-like
, CXXC finger 1 (PHD domain)
, CXXC-type zinc finger protein 1
, CpG binding protein
, PHD finger and CXXC domain-containing protein 1
, cpG-binding protein
, DNA-binding protein with PHD finger and CXXC domain
, zinc finger, CpG binding-type containing 1