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The structure of the adaptor protein fcer1g has been identified in the zebrafish genome.
mass spectrometry of WT human FcRgamma from receptor-stimulated cells shows consistent preferential phosphorylation of the serine residue at position 51.
FcgammaR-mediated Syk activation leads to NLRP3 inflammasome-dependent IL-1beta production in macrophages and suggests that an Nlrp3- and IL-1R-dependent process contributes to the IgA response important for protection against Francisella tularensis LVS.
Data indicate that the decreasing trend in the expression level of TCRzeta (show CD247 Proteins) chain, ZAP-70 (show ZAP70 Proteins) kinase and epsilon Fc Receptors FcvarepsilonRIgamma was significantly associated with disease progression.
Studies indicate that in response to stimulation with antigen, PHB1 (show PHB Proteins) translocated to plasma membrane lipid rafts to form a ternary complex with the high-affinity IgE receptor FcepsilonRIgamma and the nonreceptor tyrosine kinase (show TXK Proteins) Syk (show SYK Proteins).
High expression of FCER1G is associated with chronic myeloid leukemia (show BCL11A Proteins).
CD2-associated adaptor protein (CD2AP) positively regulates blood dendritic cell antigen 2 (BDCA2)/FcepsilonR1gamma signaling by forming a complex with SH2 domain-containing inositol 5'-phosphatase (SHIP)1 to inhibit the E3 ubiquitin ligase Cbl.
Altered expression of the TCR signaling related genes CD3 (show CD3 Proteins) and FcepsilonRIgamma in patients with aplastic anemia.
Demethylation of specific regulatory elements within the FCER1G locus contributes to FcepsilonRI overexpression on monocytes from patients with atopic dermatitis.
No associations with total and specific IgE levels as well as allergic sensitization were seen for FCER1B (show MS4A2 Proteins) and FCER1G
Conservation of FcepsilonRI gamma chain coding region in normals and in SLE patients.
CD23 deficiency impacts the early cellular event of B-cell receptor (BCR (show BCR Proteins)) activation.
Dock10 negatively regulates membrane CD23 expression; negative regulation of CD23 expression by Dock10 could play a role in B cell maturation (show TNFRSF17 Proteins) and function
data are significant in uncovering a latent, but potent, negative-regulatory role for Myd88 (show MYD88 Proteins) and Fcer1g in the late stages of B cell responses; such roles could limit acute responses; however, they could be particularly significant in chronic responses, such as autoimmunity and chronic infection
this study reveal an autonomous membrane IgE signaling mechanism that normally prevents IgE(+) memory B cells and long-lived plasma cells formation, providing insights into the molecular pathogenesis of allergic diseases.
Galectin-3 regulates IgE receptor signaling in mast cells.
these results identify a previously unproven mechanism in which epithelial CD23 plays a central role in the development of allergic inflammation
In mast cells, ORMDL3 (show ORMDL3 Proteins) functions predominantly as a negative regulator of FcepsilonRI (show FCER1A Proteins)-mediated signaling events leading to the expression of proinflammatory mediators and chemotaxis.
Data show that although phospholipase D PLD1 deficiency impaired Fc epsilon receptor FcepsilonRI-mediated signaling and mast cell function, phospholipase D PLD2 deficiency actually enhanced these pathways.
Glomerulonephritis in FcRgamma-/- chimeras was no different from wild type.
The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors.
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
, high affinity IgE receptor gamma subunit
, Fc fragment of IgE, high affinity I, receptor for, gamma polypeptide
, Fc receptor, IgE, high affinity I, gamma polypeptide
, high affinity IgE Fc receptor gamma-subunit
, Fc receptor gamma-chain
, fc-epsilon RI-gamma
, fceRI gamma
, high affinity immunoglobulin epsilon receptor subunit gamma
, immunoglobulin E receptor, high affinity, gamma chain
, gamma polypeptide
, igE Fc receptor subunit gamma
, Fc epsilon receptor gamma chain
, high-affinity IgE receptor gamma-chain