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Reduced insulin receptor substrate-1 (IRS-1) staining in lung adenocarcinoma tissue microarray displayed a significant survival disadvantage, especially within the Kirsten rat sarcoma viral oncogene (show RAB1A Proteins) homolog (KRAS) mutant subgroup.
This study examined the normal regional brain expression of IRS-1 and found a significant correlation with the volumetric associated with regional atrophy in Alzheimer's disease.
Data show that MIR126 induces autophagic flux in malignant mesothelioma (MM) cells by downregulating insulin receptor substrate-1 (IRS1) and disrupting the IRS1 signaling pathway.
IRS1/beta-Catenin (show CTNNB1 Proteins) Axis Is Activated and Induces MYC (show MYC Proteins) Expression in Acute Lymphoblastic Leukemia Cells
These effects were exerted by changes on the phosphorylation of IRS-1.
Allele and genotype frequencies of rs1801278 in IRS1 showed significant differences between cases and controls for obstructive sleep apnea risk in Chinese Han population.
Gly972Arg of IRS-1 polymorphisms are associated with polycystic ovary syndrome.
G allele of the rs7578326 SNP in the LOC646736/IRS1 region is significantly associated with gestational diabetes mellitus.
The results suggest that high glucose compromises the insulin (show INS Proteins) signaling pathway in the glomerulus, promoting a proapoptotic environment, with a possible critical step for this malfunction lying at the level of IRS-1 phosphorylation.
The C-allele of IRS1 variant rs2943650 was significantly associated with higher Body Fat Percentage overall and was significantly associated with lower levels of fasting insulin, homeostatic model assessment of insulin resistance, hemoglobin A1c, and triglycerides and higher high-density lipoprotein cholesterol in United States Hispanics/Latinos.
These results demonstrate the cooperative interaction between RPTPbeta (show PTPRZ1 Proteins) and the IGF-I receptor (show IGF1R Proteins) leading to a coordinated series of signaling events that are required for osteoblast differentiation. Our findings emphasize the important role IRS-1 plays in modulating these signaling events and confirm its essential role in facilitating osteoblast differentiation
EGCG significantly ameliorated insulin (show INS Proteins) resistance and cognitive disorder by up-regulating the insulin receptor substrate-1 (IRS-1)/AKT (show AKT1 Proteins) and ERK (show EPHB2 Proteins)/cAMP response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF (show BDNF Proteins)) signaling pathways.
Pit1 (show POU1F1 Proteins) deletion inhibited USP7 (show USP7 Proteins)/IRS1 dissociation upon insulin (show INS Proteins) stimulation.
TSH improves insulin (show INS Proteins) sensitivity in skeletal muscle by increasing Irs1 gene expression.
Insulin receptor substrate-1 time-dependently regulates bone formation by controlling collagen Ialpha2 expression via miR (show MLXIP Proteins)-342
Irs1 was downregulated in the arcuate nucleus of type 2 diabetic mice.
In conclusion, we have identified that ARL15 acts as an insulin (show INS Proteins)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1/PDPK1 (show PDPK1 Proteins)/AKT (show AKT1 Proteins) insulin (show INS Proteins) pathway by interacting with its GAP ASAP2 (show ASAP2 Proteins) and activating PDPK1 (show PDPK1 Proteins). This research may provide new insights into GTPase (show RACGAP1 Proteins)-mediated insulin (show INS Proteins) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS Proteins) sensitizati
These findings illuminate a new function of IRS-1: that of maintaining cells in their normal, differentiated state. Because IRS-1 is down-regulated in states of insulin (show INS Proteins) resistance that occur in response to metabolic stresses such as obesity and cytokine stimulation
Decreased miR (show MLXIP Proteins)-33 levels can up-regulate IRS-2 (show IRS2 Proteins) expression, which appears to compensate for the defects of the insulin (show INS Proteins) signaling pathway in Irs-1 deficient mice.
Acute knockdown of Insr or both Irs1 and Irs2 in adipocytes increased Adipoq mRNA expression but reduced adiponectin secretion.
IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (show FTO Proteins) genes regulates body weight in rabbits.
miR (show MYLIP Proteins)-146a-5p targets porcine insulin receptor (show INSR Proteins) and could inhibit its protein expression.
TBC1D4 (show TBC1D4 Proteins), insulin receptor (show INSR Proteins) and GLUT4 (show SLC2A4 Proteins) showed altered expression in some tissues in pre-diabetic pigs.
Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.
Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (show PAX6 Proteins) and a decreased cell proliferation.
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
, insulin receptor substrate 1
, insulin receptor substrate 1-A