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Rat (Rattus) KL Protein expressed in Escherichia coli (E. coli) - ABIN2123130
Wu, Lv, Chen, Ma, Shao, Wang: The function of miR-199a-5p/Klotho regulating TLR4/NF-?B p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism. in Molecular and cellular endocrinology 2015
We show that rosiglitazone increases klotho and decreases Wnt5A (show WNT5A Proteins) in tumor cells, reducing the burden of both BRAF (show BRAF Proteins) inhibitor-sensitive and BRAF (show BRAF Proteins) inhibitor-resistant tumors in aged, but not young mice. However, when used in combination with PLX4720, tumor burden was reduced in both young and aged mice, even in resistant tumors
Klotho suppresses Sox9 (show SOX9 Proteins) upregulation and intranuclear translocation. Klotho inhibits high phosphate-induced osteogenic activity in human aortic valve interstitial cells.
Data suggest that serum levels of alpha-klotho and beta-klotho (show KLB Proteins) are down-regulated in patients with type 2 diabetes, regardless of diabetic complications.
Low expression levels of Klotho were observed in DLBCL patients and cell lines. Enforced expression of Klotho could significantly induce cell apoptosis and inhibit tumor growth in DLBCL. Upregulation of Klotho resulted in declined activation of IGF-1R signaling, accompanied with decreased phosphorylation of its downstream targets, including AKT and ERK1/2.
Data suggest that plasma alpha-klotho is down-regulated in subjects with type 2 diabetes as diabetic nephropathy progresses; plasma alpha-klotho level (not urinary alpha-klotho level) may be an early biomarker for predicting renal impairment in type 2 diabetes.
Hmgb1 (show HMGB1 Proteins) can inhibit Klotho gene expression and malignant phenotype in melanoma cells through activation of NF-kappaB (show NFKB1 Proteins) signaling.
patients with autosomal dominant polycystic kidney disease may potentially have different soluble alpha-Klotho production/clearance characteristics than the patients with other parenchymal renal diseases.
KL and SFRP1 (show SFRP1 Proteins) methylation were more predominant in nasopharyngeal tumors.
A statistically significant positive correlation was found between s-Klotho and FGF23 (show FGF23 Proteins) (r=0.768; p=0.001), and between FGF23 (show FGF23 Proteins) levels and urinary albumin (show ALB Proteins) creatinine ratio (r=0.768; p=0.001).
The beta-Klotho gene expresses only in retina and optic nerve. The gamma-Klotho gene may regulate human lens epithelial cells' function mainly by the MAPK/ERK1/2 signaling pathway.
The present study provides a novel approach for klotho gene therapy and demonstrates that direct up-regulation of klotho in the brain might improve aging-related memory impairments and decrease oxidative stress.
Klotho inhibits cigarette smoke-induced autophagy via down-regulation of IGF-1R (show IGF1R Proteins), Akt (show AKT1 Proteins), and ERK (show EPHB2 Proteins) phosphorylation in alveolar macrophages.
In conclusion, the excessive 1,25(OH)2D3 formation in klotho-hypomorphic mice has a profound effect on murine behavior.
Klotho is a novel regulator of postnatal neurogenesis affecting neural stem cell proliferation and maturation sufficient to impact hippocampal-dependent spatial memory function.
Reduced Klotho expression aggravates tacrolimus-induced renal injury via the PI3K-Akt (show AKT1 Proteins)-FoxO (show FOXO3 Proteins) pathway.
Two distinct isoforms of soluble Klotho appear to play counter-regulatory roles in cardiac fibrogenic responses.
Klotho regulates adipogenic differentiation in adipose-derived stem cells, likely via inhibition of TGFbeta1 (show TGFB1 Proteins) and activation of PPAR-gamma (show PPARG Proteins).
Review of Klotho function and dysfunction in mice and humans. [Review Article]
Overexpression of Klotho inhibits the differentiation of RAW264.7 cells into osteoclasts.
Data suggest that klotho affects cognition, at least in part, by regulating hippocampal synaptic plasticity.
Activated HAT activity of p300 (show EP300 Proteins) modulates AV calcification through osteogenic transdifferentiation of VICs with Klotho modulation.
Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Proteins)-RUNX2 (show RUNX2 Proteins) pathway.
significant expression of FGF23 (show FGF23 Proteins) and KL within the growth plate and adjacent tissues imply a potential local role of FGF23 (show FGF23 Proteins) in chondrocyte differentiation and tissue mineralization.
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
, kit ligand
, secreted form of Klotho protein