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Rat (Rattus) KL Protein expressed in Escherichia coli (E. coli) - ABIN2123130
Wu, Lv, Chen, Ma, Shao, Wang: The function of miR-199a-5p/Klotho regulating TLR4/NF-?B p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism. in Molecular and cellular endocrinology 2015
Klotho is expressed and upregulated in diseased hearts
Levels of alpha-Klotho and beta-Klotho were downregulated in patients in the T2 diabetes mellitus (T2DM) and complications groups. Our findings indicate that serum Klotho levels were associated with the development of T2DM, and long-term control of blood glucose will be beneficial in ameliorating changes to alpha-Klotho and beta-Klotho levels in patients with T2DM and complications.
We hypothesize a probable protective effect of KL on frailty in the elderly population and included a cohort of Chinese nonagenarians and centenarians for our study. ..KL-395A allele carrying genotypes (GA and AA) is associated with a lower risk of frailty relative to GG genotypes in a sample of Chinese nonagenarians and centenarians
Our data indicate klotho KL1 as a regulator of metabolic activity in breast cancer and suggest that metabolic alterations underlie KL1 tumor suppressor activities.
Klotho C1818T variant may be associated with a decreased risk of hypertension. KLOTHO gene might play a part in the age-related occurrence of coronary artery disease combined with hypertension.
Results indicate that physical activity and physical fitness levels are associated with S-Klotho plasma levels in middle-aged sedentary adults.
Notch-mediated Klotho hypermethylation inhibited Klotho expression, which promoted inflammatory response and cell apoptosis that were associated with the development of COPD.
Klotho and FGF23 are associated with cardiovascular risk in the early stages of chronic kidney disease.
The preservation of Klotho gene expression might induce the antioxidative stress mechanism for homeostasis of healthy human kidney independently of its general condition, including age, renal function, and histological findings.
Cigarette smoke induces airway inflammation by downregulation of Klotho and activation of FGFR4 in the airway epithelium in chronic obstructive pulmonary disease
this meta-analysis assessed the associations between two polymorphisms (G-395 A/rs1207568 and F352 V/rs9536314) and five parameters (urolithiasis, cognitive impairment, cardiovascular disease, cancer, and longevity) by calculating pooled odds ratios with 95% confidence intervals.[meta-analysis]
aldosterone significantly inhibited H3K9 acetylation by upregulating HDAC1 protein expression levels in the renal distal convoluted tubule cells, resulting in its inability to bind to the KL promoter
found a stimulatory effect of acute and chronic exercises on plasma IGF-I and Klotho and association of IGF-I with exercise-induced cardiac hypertrophy. Moreover, Klotho could act as a negative regulator for exercise-induced cardiac hypertrophy.
KL is a negative regulator of aerobic glycolysis and KL inhibited glucose metabolism transformation via the ERK/ HIF1alpha axis
Klotho protein function among patients with type 1 diabetes is reviewed.
Total alcoholic drinks consumption is negatively associated with the soluble form of alpha-Klotho plasma levels in middle-aged sedentary adults.
klotho protein could be considered as a protective factor against immunosenescent-like phenotype in monocytes an issue relevant to many immune disorders.
Results uncover a major mechanism of iPSC action, suggest a fundamental role of alphaKlotho in iPSC maintenance, and support the translational potential of airway delivery of cell-free iPSC secretome for protection against lung injury.
Serum klotho was an independent biomarker of left ventricular hypertrophy, but not arterial stiffness.
Gene expression array revealed that klotho and KL1 expression enhanced the unfolded protein response (UPR) and this was further established by increased levels of spliced XBP1, GRP78 and phosphorylated-eIF2alpha.
These results demonstrate that the protective effect of Klotho on diabetes-induced cardiac injury is associated with inhibition of the NLRP3 inflammasome pathway, suggesting its therapeutic potential for diabetic cardiomyopathy.
Suggest an important interplay between the PTH/PTH1R and FGF23/Klotho pathways to affect renal phosphate handling in the proximal tubules.
that klotho was expressed in glomerular podocytes that and its expression was regulated by PPARgamma
Nicotine downregulates renal Klotho expression. Renal and autonomic responses to nicotine exposure are modified in kl haploinsufficient mice.
data suggest that Klotho deficiency causes thymic involution via systemic effects that include high active vitamin D levels
Uchl1-deleted mice exhibit perturbed phosphate homeostasis, likely consequent to decreased urinary soluble alpha-klotho, which can be rescued with a low-phosphate diet.
It is a antiaging gene and its upregulation of cerebral expression treats and prevents Alzheimer's disease-like pathology and cognitive deficits.
Despite the profound, aldosterone-mediated increase in circulating intact Fgf23 after TAC, our data do not support an essential role of Fgf23 or Klotho in the pathophysiology of pressure overload-induced cardiac hypertrophy.
These findings therefore, indicate a protective role for KL against osteoblastic cell apoptosis induced by dexamethasone, via the NF-kappaB signaling pathway.
Data show that MiR-199a could regulate the activation of NF-kappa B (NF-kappaB) by directly targeting Klotho protein.
Depleting klotho selectively from the choroid plexus via targeted viral vector-induced knockout in Klotho mice increased the expression of multiple proinflammatory factors and triggered macrophage infiltration.
The present study analyzed the gene expression profile in salivary glands from accelerated aging klotho deficient mice.
The studies identify a role for alpha-Klotho in the regulation of muscle progenitor cell mitochondrial function and implicate alpha-Klotho declines as a driver of impaired muscle regeneration with age.
our study identified Klotho loss as a key event linking HDAC deregulation to the renal and bone injuries in CKD-MBD mice and demonstrated the therapeutic potentials of endogenous Klotho restoration by HDAC inhibition in treating CKD and the associated extrarenal complications.
Klotho has posed antioxidant and anti-apoptotic effects on oxidative injuries in TCMK-1 cells, which might be partially related to its inhibition of JNK/MAPK and p38/MAPK phosphorylation and subsequent elevation of antioxidant enzymes. Increasing Klotho expression has played a protective role against oxidative stress in tubular epithelial cells.
Klotho expression in the central nervous system is associated with total antioxidant capacity in mice with experimental autoimmune encephalomyelitis.
Using mouse strains with parathyroid-specific deletions of Klotho and CaSR and dual deletion of both genes, Klotho has a pivotal role in suppressing PTH in the absence of CaSR. Chronic hypocalcemia and ex vivo PTG culture demonstrated an independent role for Klotho in mediating PTH secretion.
DPP-4 inhibition with linagliptin slowed the progression of premature aging in klotho-/- mice. Provide a novel insight into the potential role of DPP-4 in the mechanism of premature aging.
Activated HAT activity of p300 modulates AV calcification through osteogenic transdifferentiation of VICs with Klotho modulation.
Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha-RUNX2 pathway.
significant expression of FGF23 and KL within the growth plate and adjacent tissues imply a potential local role of FGF23 in chondrocyte differentiation and tissue mineralization.
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
secreted form of Klotho protein