anti-Human LAT2 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended LAT2 Antibody (supplied by: Log in to see )

Antigen
Linker For Activation of T Cells Family, Member 2 (LAT2) Antibodies
  • LAB
  • NTAL
  • WBSCR15
  • WBSCR5
  • WSCR5
  • LAT2
  • MGC139435
  • Ntal
  • Wbscr5
  • AW125574
  • Wbscr15
  • linker for activation of T-cells family member 2
  • linker for activation of T cells family, member 2
  • LAT2
  • Lat2
Epitope
AA 91-243, Cytoplasmic Domain
15
14
11
11
11
10
8
8
6
5
5
5
5
2
2
2
2
2
2
2
1
1
1
1
1
Reactivity
Human
117
36
24
3
3
3
1
1
1
1
1
Host
Rabbit
94
36
14
1
Clonality
Polyclonal
Conjugate
This LAT2 antibody is un-conjugated
8
6
6
3
3
3
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
134
43
32
29
21
15
12
6
5
3
3
2
1
1
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Catalog No. ABIN302075
$ 428.84
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
17.780954 ABIN94442 IHC (p) IP WB Mouse IgG2a AA 196-212 Log in to see NAP-03 2
11.5841255 ABIN239823 Inhibition IHC IHC (p) IP WB Mouse IgG2a AA 196-212 Log in to see NAP-03 0
8.5841255 ABIN615294 IHC (p) WB Rabbit AA 91-243, Cytoplasmic Domain Log in to see Polyclonal 0
8.458544 ABIN4340810 IHC IHC (p) WB Rabbit IgG Log in to see Polyclonal 0
7 ABIN462419 Inhibition IHC IHC (p) WB Rabbit AA 91-243 Log in to see Polyclonal 0
7 ABIN238343 IHC (p) WB Rabbit AA 91-243 Log in to see Polyclonal 3
7 ABIN5582405 IHC (p) WB Rabbit IgG Log in to see Polyclonal 0
4 ABIN1385433 IF (p) IHC (p) Rabbit IgG AA 1-20 Log in to see Polyclonal 0
4 ABIN1723375 IHC (p) IP WB Mouse IgG2a AA 196-212 Log in to see NAP-03 0
4 ABIN1736369 IHC (p) WB Rabbit IgG Cytoplasmic Domain, AA 91-243 Log in to see Polyclonal 0
4 ABIN5582404 IHC (p) IP WB Mouse IgG2a Log in to see NAP-03 0
1 ABIN120728 IHC (p) IP WB Mouse IgG1 AA 196-212 Log in to see NAP-03 1
1 ABIN2742549 IHC IHC (p) WB Rabbit AA 124-203 Log in to see Polyclonal 0
1 ABIN2742551 IHC IHC (p) WB Rabbit AA 91-243 Log in to see Polyclonal 0
1 ABIN3200729 IHC (p) IP WB Mouse IgG2a Log in to see NAP-03 0
1 ABIN3200726 IHC (p) WB Rabbit Cytoplasmic Domain Log in to see Polyclonal 0
-5.1255817 ABIN4340808 IHC IHC (p) WB Rabbit AA 91-243 Log in to see Polyclonal 0
-11.125582 ABIN269148 IHC (p) IP IHC WB Mouse IgG2a AA 196-212 Log in to see NAP-03 0
-11.125582 ABIN4340830 IHC IHC (p) WB Alexa Fluor 405 Mouse IgG2a AA 196-212 Log in to see NAP-03 0
-11.125582 ABIN4340831 IHC IHC (p) WB Alexa Fluor 488 Mouse IgG2a AA 196-212 Log in to see NAP-03 0

General

Antigen Linker For Activation of T Cells Family, Member 2 (LAT2) Antibodies
Epitope AA 91-243, Cytoplasmic Domain
(15), (14), (11), (11), (11), (10), (8), (8), (6), (5), (5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity Human
(117), (36), (24), (3), (3), (3), (1), (1), (1), (1), (1)
Host Rabbit
(94), (36), (14), (1)
Clonality
Polyclonal
Conjugate This LAT2 antibody is un-conjugated
(8), (6), (6), (3), (3), (3), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(134), (43), (32), (29), (21), (15), (12), (6), (5), (3), (3), (2), (1), (1)
Pubmed 3 references available
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Product Details anti-LAT2 Antibody

Target Details LAT2 Application Details Handling References for anti-LAT2 antibody (ABIN302075) Images
Specificity The polyclonal antibody recognizes the defined epitope (aa 91-243) of human Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 30 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.
No Cross-Reactivity Mouse (Murine)
Cross-Reactivity (Details) Human
Purification Purified from rabbit serum by affinity chromatography
Purity > 95 % (by SDS-PAGE)
Immunogen Recombinant cytoplasmic domain (aa 91-243) of human NTAL.
Plasmids, Primers & others

Target Details LAT2

Product Details anti-LAT2 Antibody Application Details Handling References for anti-LAT2 antibody (ABIN302075) Images back to top
Antigen
Alternative Name NTAL / LAB (LAT2 Antibody Abstract)
Background NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
Pathways Fc-epsilon Receptor Signaling Pathway

Application Details

Product Details anti-LAT2 Antibody Target Details LAT2 Handling References for anti-LAT2 antibody (ABIN302075) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-LAT2 Antibody Target Details LAT2 Application Details References for anti-LAT2 antibody (ABIN302075) Images back to top
Concentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.

References for anti-LAT2 antibody (ABIN302075)

Product Details anti-LAT2 Antibody Target Details LAT2 Application Details Handling Images back to top
Background publications

Yamasaki, Ishikawa, Sakuma, Kanagawa, Cheng, Malissen, Saito: "LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival." in: Molecular and cellular biology, Vol. 27, Issue 12, pp. 4406-15, 2007

Horejsí, Zhang, Schraven: "Transmembrane adaptor proteins: organizers of immunoreceptor signalling." in: Nature reviews. Immunology, Vol. 4, Issue 8, pp. 603-16, 2004

Product cited in:

Tkaczyk, Horejsi, Iwaki, Draber, Samelson, Satterthwaite, Nahm, Metcalfe, Gilfillan: "NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation." in: Blood, Vol. 104, Issue 1, pp. 207-14, 2004

Images

Product Details anti-LAT2 Antibody Target Details LAT2 Application Details Handling References for anti-LAT2 antibody (ABIN302075) back to top
Supplier Images
Western Blotting (WB) image for anti-Linker For Activation of T Cells Family, Member 2 (LAT2) (AA 91-243), (Cytoplasmic Domain) antibody (ABIN302075) Western Blotting analysis (non-reducing conditions) of NTAL-transfected HEK-293 FT ce...
Immunohistochemistry (IHC) image for anti-Linker For Activation of T Cells Family, Member 2 (LAT2) (AA 91-243), (Cytoplasmic Domain) antibody (ABIN302075) Immunohistochemistry staining of human spleen (paraffin sections) with anti-NTAL poly...