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The AML1 (show RUNX1 Proteins)/ETO (show RUNX1T1 Proteins) target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells.
LAT2 is an early mediator of the anti-leukemic activity of alkylphospholipids and arsenic trioxide. Thus, LAT2 may be used as a target for the design of drugs for cancer therapy.
NTAL acts as a tumor suppressor that enhances the proximal signaling of leukemic blasts. The key downstream molecule responsible for the biological effect of TCR signaling is ERK (show EPHB2 Proteins).
LAT2 protein (NTAL) participates in the activation of the c-Met-Grb2 (show GRB2 Proteins)-ERK (show EPHB2 Proteins)-cPLA2 (show PLA2G4A Proteins) signalling cascade at early stages of H. pylori infection.
data show that NTAL (non-T cell activation linker) appears to be a structural and possibly also functional homologue of LAT (linker for activation of T cells (show LAT Proteins))in non-T cells [non-T cell activation linker]
LAB links BCR (show BCR Proteins) engagement to downstream signaling pathways.
LAB was primarily phosphorylated on three membrane-distal tyrosines, Tyr (show TYR Proteins)(136), Tyr (show TYR Proteins)(193), and Tyr (show TYR Proteins)(233). Mutation of these three tyrosines abolished Grb2 (show GRB2 Proteins) binding and LAB function
LAB resembled a LAT (show ORC3 Proteins) molecule unable to bind phospholipase C (show PLC Proteins)-gamma1.
The NTAL/LAB is expressed in a variety of immune cells.
NTAL acts as a negative regulator of TNF-alpha (show TNF Proteins) and IL-8 (show IL8 Proteins) production after stimulation via TREM-1 (show TREM1 Proteins)
NTAL is a negative regulator of FcepsilonRI (show FCER1A Proteins) activation events in murine bone marrow-derived mast cells, independently of possible compensatory developmental alterations.
Cerebral cortex hyperthyroidism of newborn mct8 (show MCT8 Proteins)-deficient mice transiently suppressed by lat2 (show SLC7A8 Proteins) inactivation.
Our data define a novel link between LAB and beta-catenin (show CTNNB1 Proteins) nuclear accumulation in dendritic cells that facilitates IFN-gamma (show IFNG Proteins) responses during anti-fungal immunity
chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI (show FCER1A Proteins), tetraspanin CD9 (show CD9 Proteins), transmembrane adaptor proteins NTAL and LAT (show LAT Proteins), and cytoskeleton-regulatory proteins of the ERM (show ETV5 Proteins) family
Dihydrotestosterone treatment increased the expression of LAT2 (show SLC7A8 Proteins).
The expression of Mct8 (show MCT8 Proteins) and L-type amino acid transporters Lat2 (show SLC7A8 Proteins) and Lat1 (show SLC7A5 Proteins) are determined in brain neurons during development.
a crucial role of NTAL in signaling, via RhoA (show RHOA Proteins), to mast cell cytoskeleton.
While SLP-76 (show LCP2 Proteins) and LAT1 (show SLC7A5 Proteins) depend on each other for many of their functions, LAT2 (show SLC7A8 Proteins)/SLP-76 (show LCP2 Proteins) interactions and SLP-76 (show LCP2 Proteins)-independent LAT1 (show SLC7A5 Proteins) functions also mediate a positive signaling pathway downstream of FcepsilonRI (show FCER1A Proteins) in mast cells.
LAB is a critical, LAT (show LAT Proteins)-independent regulator of TREM-2 (show TREM2 Proteins) signaling and macrophage development capable of controlling subsequent inflammatory responses
NTAL negatively regulates Fc-epsilon receptor I-mediated signaling events in bone marrow-derived mast cells.
This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.
Williams-Beuren syndrome chromosomal region 15 protein
, Williams-Beuren syndrome chromosomal region 5 protein
, linker for activation of B-cells
, linker for activation of T cells, transmembrane adaptor 2
, linker for activation of T-cells family member 2
, membrane-associated adapter molecule
, non-T-cell activation linker
, Williams-Beuren syndrome chromosome region 5 homolog
, non-T cell activation linker
, linker for activation of T cells family, member 2
, Williams-Beuren syndrome chromosome region 5-like protein
, Williams-Beuren syndrome chromosome region 15 homolog
, williams-Beuren syndrome chromosomal region 15 protein homolog