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Fyn and Lyn as important factors that promote Plasmacytoid dendritic cell responses.
these findings demonstrated that Lyn overexpression ameliorated airway mucus hypersecretion by down-regulating STAT6 and its binding to the MUC5AC promoter.
overexpression LYN promoted tumor growth, meanwhile knockdown LYN inhibited tumor growth. These results indicate that LYN tyrosine kinase is an oncogenic gene and can serve as a novel target for cervical cancer research and therapy.
LYN is a useful prognostic marker and a selective target of dasatinib therapy in the lung adenocarcinoma subpopulation, especially in female non-smokers with lung adenocarcinoma.
SHP-1 tyrosine 536 phosphorylation by Lyn activates the phosphatase promoting inhibitory signaling through the immunoreceptor.
A novel pancancer mechanism of Lyn-dependent control of epithelial-mesenchymal transition and role of this kinase in tumor progression.
Authors demonstrate that LYN kinase is essential for CLL progression. Lyn deficiency results in a significantly reduced CLL burden in vivo.
Our studies indicate not only a concept of mucus hypersecretion in asthma that involves Lyn kinase but also an important therapeutic candidate for asthma.
LPS tolerance interferes with TLR4 signaling by inhibiting Lyn and c-Src phosphorylation and their recruitment to TLR4, while increasing the phosphatase activity and expression of PP2A, PTPN22, PTP1B and MKP1.
SYK, LYN and PTPN6 were markedly elevated in atherosclerotic plaques of carotid atherosclerosis patients.
Our data suggests that nuclear Lyn is a potential therapeutic target for clear cell renal cell carcinoma and dasatinib affects cellular functions associated with cancer progression via a Src kinase independent mechanism.
Authors discovered in this study that LYN was a critical gene. It was found to be the key nodule of several significant biological networks.
Inhibition of Lyn activity using dasatinib in mantle cell lymphoma overcomes bortezomib resistance.
positively regulates NF-kappaB transactivation through the phosphorylation of the p110 subunit of PI 3-kinase
This study showed an interdependence between ROS generation and lipid rafts and Lyn relocation leading the cells to undergo the successive acrosome reaction.
SRC, LYN and CKB expression or DNA methylation could be useful markers for predicting tumor progression.
Suggest an interrelated kinase module involving c-Raf/PI3K/Lyn and perhaps Fgr functions in a nontraditional way during retinoic acid-induced maturation or during rescue of RA induction therapy using inhibitor co-treatment in RA-resistant leukemia cells.
Diminished Lyn levels impair Claudin-2 expression in breast cancer cells. The Lyn-selective kinase inhibitor, Bafetinib (INNO-406), reduces Claudin-2 expression and suppresses breast cancer liver metastasis.
Demonstrate role for CBL in the control of AXL/SYK/LYN network mediating resistance to nilotinib treatment in chronic myeloid leukemia cells.
Fyn, but not Lyn, was required for complete Pyk2 phosphorylation by thrombin.
these results reveal a role for Lyn as a specific suppressor of the TLR-MyD88-IRF5 pathway and illustrate the importance of fine-tuning IRF5 activity for the maintenance of immune homeostasis
These findings reveal that the function and regulation of Lyn during B1 cell B cell receptor signaling is distinct from other B cell subsets.
A mutation in LYN, an inhibitory protein tyrosine kinase that is implicated in systemic autoimmunity, combines with an Aire mutation to provoke organ-specific autoimmunity.
the Hck, Fgr and Lyn kinases are also necessary for amastigote uptake by macrophages. Src-mediated Arg activation is required for efficient uptake.
the Lyn mutation in NOD neutrophils is likely responsible for dysregulation of neutrophil adhesion and directed migration.
Together, the basal-state signaling checkpoint regulated by LynA expression and degradation and the signaling reorganization initiated by receptor clustering allow cells to discriminate optimally between pathogens and nonpathogens.
Oxidized LDL-bound CD36 recruits an Na/K-ATPase-Lyn complex in macrophages that promotes atherosclerosis.
Lyn kinase modulates inhibitory signaling to suppress endotoxin-induced lung inflammation.
A complex functional interplay between FcgammaRIIa, Lyn, and alphaIIbbeta3 in immune complex-induced platelet activation.
report that Lyn is required for bacterial infection-induced recruitment of autophagic components to pathogen-containing phagosomes
Data indicate interactions between Ets1 transcription factor and two of its important regulators: Lyn, which maintains Ets1 expression to limit the differentiation of autoreactive plasma cells (PCs), and Btk.
results indicate that Lyn plays a positive regulatory role in RIG-I-mediated interferon expression as a downstream component of IPS-1
Data show that tyrosine protein kinase Lyn acts as a sensor of hydrogen peroxide (H2O2) levels to facilitate microglial migration toward alpha-Synuclein (alpha-syn).
Lyn is a key regulator of survival signaling in plasma cells, limiting plasma cell accumulation and autoimmune disease susceptibility.
Lyn is a key regulator of the mucosal immune system, governing pathophysiology in multiple models of intestinal disease.
results explain how early H2O2 signal regulates neutrophil recruitment at all phases, directly via Lyn oxidation or indirectly by modulating cxcl8 gene expression
identify the Src family kinase (SFK) Lyn as a redox sensor that mediates initial neutrophil recruitment to wounds in zebrafish larvae
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
lck/Yes-related novel protein tyrosine kinase
, tyrosine-protein kinase Lyn
, Tyrosine-protein kinase Lyn
, lyn protein tyrosine kinase
, lyn protein non-receptor kinase
, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
, v-yes-1 Yamaguchi sarcoma viral related oncogene protein-like protein
, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
, Yamaguchi sarcoma viral (v-yes-1) oncogene homolog