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Human NR4A3 Protein expressed in Wheat germ - ABIN1312985
Medunjanin, Daniel, Weinert, Dutzmann, Burgbacher, Brecht, Bruemmer, Kähne, Naumann, Sedding, Zuschratter, Braun-Dullaeus: DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1. in Cardiovascular research 2015
In the 3 cases of the primary extraskeletal myxoid chondrosarcoma (EMC) of bone we found the most frequent and specific chromosomal translocation t(9:22) EWSR1 (show EWSR1 Proteins)-NR4A3 of the extraskeletal counterpart.
Results indicate that NOR-1 regulate SMPX (show SMPX Proteins) in human muscle cells and acts as a muscle regulatory factor to promote myotube differentiation.
NR4A sub-family of nuclear orphan receptors (Nor-1, Nurr-1 (show NR4A2 Proteins) and Nur-77 (show NR4A1 Proteins)) may have a role in trophoblastic cell differentiation.
VTN (show VTN Proteins) levels were increased in cell supernatants from vascular smooth muscle cells that overexpress NOR-1
NR4A2 (show NR4A2 Proteins) and NR4A3 are components of a downstream transcriptional response to PKA activation in the neutrophil, and that they positively regulate neutrophil survival and homeostasis.
NOR1 suppresses cancer stem-like cell properties in nasopharyngeal carcinoma cells by inhibiting the AKT (show AKT1 Proteins)-GSK-3beta-Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-ALDH1A1 (show ALDH1A1 Proteins) signaling circuit.
Transcript analysis of four different aggressive lymphoma cell lines overexpressing either NR4A3 or NR4A1 (show NR4A1 Proteins) revealed that apoptosis was driven similarly by induction of BAK (show BAK1 Proteins), Puma (show BBC3 Proteins), BIK (show BIK Proteins), BIM (show BCL2L11 Proteins), BID (show BID Proteins), and Trail. Overall, our results showed that NR4A3 possesses robust tumor suppressor functions of similar impact to NR4A1 (show NR4A1 Proteins) in aggressive lymphomas
Study found a marked down-regulated gene expression of the NR4A subfamily (NR4A1 (show NR4A1 Proteins), NR4A2 (show NR4A2 Proteins), and NR4A3) obtained from Parkinson's disease patients, but only a NR4A1 (show NR4A1 Proteins) decrease in Alzheimer's disease patients compared to healthy controls. This study reports that the entire NR4A subfamily and not only NR4A2 (show NR4A2 Proteins) could be systemically involved in Parkinson's disease.
the role of intragenic DNA hypermethylation in reducing the expression of NR4A3 in AML (show RUNX1 Proteins)
Overexpression of NR4A3 in adipocytes produces a complex phenotype characterized by impaired glucose metabolism and low serum catecholamines due to enhanced degradation by adipose tissue.
Nor-1 expression drives multiple physiological changes/pathways that are critical to the beneficial responses of muscle to exercise.
these results show that NR4A3 is involved in TLR-mediated activation and gene expression of dendritic cells
NR4A3 plays an important role in the regulation of CD103 (show ITGAE Proteins)+ mDCs by regulating CCR7 (show CCR7 Proteins)-dependent cell migration.
Study shows that NOR-1 can transduce survival signals in neuronal cells responsible for hypoxiainduced apoptotic insults through activation of a CREB (show CREB1 Proteins)/cIAP2 (show BIRC3 Proteins)-dependent mechanism
Promoting Liver X receptor-alpha (show NR1H3 Proteins) expression inhibits lipopolysaccharide induced inflammation in Kupffer cells through elevating NOR-1 expression.
Identified Nur77 (show NR4A1 Proteins)/Nor1 as novel regulators of thrombomodulin (show THBD Proteins) expression and function in vascular endothelial cells.
Nr4a3 factor plays crucial role regulatory T cells, mediating the two defining characteristics of regulatory T cells: stability of cell lineage and immunosuppressive functions.
Studies demonstrate that NOR1 deletion in hematopoietic stem cells accelerates atherosclerosis formation by promoting myelopoiesis in the stem cell compartment and by inducing local proatherogenic activities in the macrophage.
Our data support a role for NOR-1 as a negative modulator of the acute response elicited by pro-inflammatory stimuli in the vasculature.
Results indicate that DNA hypomethylation of the CpG island at Nr4a3 exon 3 is associated with low Nr4a3 expression, and correlates with poor prognosis of neuroblastoma (show ARHGEF16 Proteins).
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene.
chondrosarcoma, extraskeletal myxoid, fused to EWS
, mitogen-induced nuclear orphan receptor
, neuron-derived orphan receptor 1
, nuclear hormone receptor NOR-1
, nuclear receptor subfamily 4 group A member 3
, translocated in extraskeletal chondrosarcoma
, neural orphan receptor 1
, orphan nuclear receptor TEC
, neuron-derived orphan receptor 1/2
, nuclear hormone receptor NOR-1/NOR-2
, nuclear receptor subfamily 4, group A, member 3
, neural orphan nuclear receptor NOR1