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study reports that neutrophils constitutively express various Src (show SRC Proteins) family isoforms as well as Syk, and that inhibition of these protein tyrosine kinases selectively hinders inflammatory cytokine generation by acting posttranscriptionally
Cholesterol crystals activate specific cell signalling pathways which drive the production of inflammatory cytokines and degradative enzymes known to contribute to disease initiation and progression and are dependent on activation of Syk and PI3K (show PIK3CA Proteins)
Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C (show PLC Proteins) gamma1 (PLCgamma1 (show PLCG1 Proteins)) in osteogenesis and PLCgamma2 (show PLCG2 Proteins) in adipogenesis.
AKT (show AKT1 Proteins) and 14-3-3 (show YWHAQ Proteins) proteins down-regulate the activity of several BCR (show BCR Proteins)-associated components, including BTK (show BTK Proteins), BLNK (show BLNK Proteins) and SYK and also inhibit SYK's interaction with Importin 7 (show IPO7 Proteins)
Expression of SYK and its splice variants was significantly lower in tumors with MSI, and in KRAS wild type, BRAF mutant and PTEN mutant tumors
combined use of butyrate and highly specific Syk inhibitor BAY61-3606 does not enhance differentiation and apoptosis of colonocytes. Instead, BAY completely abolishes butyrate-induced differentiation and apoptosis in a Syk- and ERK1/2-dependent manner.
Study demonstrates that redundant complexes formed by the mutant SYK(Y3F) protein allow it to maintain signaling to receptor-proximal interaction partners, resulting in proper initiation of BCR (show BCR Proteins)-proximal signals.
The study identified the criteria for the design of binders that specifically address either the Syk or the Zap-70 (show ZAP70 Proteins) Tandem Src (show SRC Proteins) Homology 2 Domains, tSH2. While Syk tSH2 has a rather broad substrate scope, ZAP-70 (show ZAP70 Proteins) tSH2 required a proximal arrangement of the phosphotyrosine ligands in defined strand orientation.
SYK mediates the actions of EPO (show EPO Proteins) and GM-CSF (show CSF2 Proteins) and coordinates with TGF-beta (show TGFB1 Proteins) in erythropoiesis.
study demonstrates that high SYK expression is a common feature of CD21 (show CR2 Proteins)(low) B cells independent of the underlying disorder, and that this high expression is sufficient to drive constitutive phosphorylation of SYK and its immediate targets Bruton's tyrosine kinase (show BTK Proteins) and phospholipase Cgamma2
SYK could induce HO-1 (show HMOX1 Proteins) expression by regulating the Akt (show AKT1 Proteins) phosphorylation level in H9c2 with A/H injury, protecting H9c2 from the injury induced by A/H treatment.
identified both Syk and Src (show SRC Proteins) signaling pathways as ones that participate in Borrelia burgdorferi phagocytosis and the resulting cytokine activation.
These results identify Syk as a critical component of skin inflammation in a mouse model of epidermolysis bullosa acquisita
Syk was identified as the target enzyme most strongly inhibited by water extract of Cordyceps bassiana.
The downmodulation of Syk expression and phosphorylation in intestinal DCs could be important mechanisms through which helminths induce regulatory DCs that limit colitis.
ephrin B3 (show EFNB3 Proteins)/EphB2 (show EPHB2 Proteins) are obvious candidates for driving the Syk-dependent repulsive response.
IgG (mAb)-opsonized, inactivated Francisella tularensis LVS enhances macrophage and dendritic cell IL-1beta (show IL1B Proteins) responses in a TLR2- and FcgammaR-dependent fashion. FcgammaR-mediated Syk activation leads to NLRP3 (show NLRP3 Proteins) inflammasome-dependent IL-1beta (show IL1B Proteins) production in macrophages.
The effect of Smad4 (show SMAD4 Proteins) was at least partially mediated by the downstream effectors Syk and ROCK2 (show ROCK2 Proteins) transcription in megakaryocytes.
These data suggest that Syk mRNA expression dynamics is closely related to bovine leukemia virus-induced disease.
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tyrosine-protein kinase SYK
, tyrosine-protein kinase SYK
, protein-tyrosine kinase