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anti-Human VAV2 Antibodies:
anti-Rat (Rattus) VAV2 Antibodies:
anti-Mouse (Murine) VAV2 Antibodies:
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Human Polyclonal VAV2 Primary Antibody for ELISA, WB - ABIN257860
Henske, Short, Jozwiak, Bovey, Ramlakhan, Haines, Kwiatkowski: Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1. in Annals of human genetics 1995
Human Polyclonal VAV2 Primary Antibody for IHC, IHC (p) - ABIN4364881
Zhu, Zhao, Wu, Yang, Shao, Wang, Wu, Yin, Li, Hou, Zhang, Zhou, Gu, Wang, Bustelo, Zhou: Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking. in Nature neuroscience 2015
High VAV2 expression is associated with breast cancer.
Manipulating steroidogenic factor-1 (SF-1 (show NR5A1 Antibodies)) and nucleotide exchange factor VAV-2 (VAV2) abundance in cultured adrenocortical carcinoma (ACC (show ACACA Antibodies)) cells indicate that VAV2 was a critical factor for SF-1 (show NR5A1 Antibodies)-induced cytoskeletal remodeling and invasion in culture and in vivo (chicken chorioallantoic membrane) models.
Data indicate that phosphorylated cortactin recruits Vav2 to activate Rac3 and promote invadopodial maturation in invasive breast cancer cells.
autocrine VEGF (show VEGFA Antibodies) and IL-8 (show IL8 Antibodies) promoted endothelial cell migration via the Src (show SRC Antibodies)/Vav2/Rac1/PAK1 (show PAK1 Antibodies) signaling pathway.
We concluded that Vav2 might promote invasion and metastasis of gastric cancer by regulating some invasion and metastasis-related genes.
work suggested that EphB3 (show EPHB3 Antibodies) acted as a tumor promoter in Papillary Thyroid Cancer by increasing the in vitro migration as well as the in vivo metastasis of Papillary Thyroid Cancer cells through regulating the activities of Vav2 and Rho GTPases in a kinase-dependent manner.
The crystal structure of the complex between a phosphorylated PPxY motif of TXNIP (show TXNIP Antibodies) and the SH2 domain of Vav2 reveals a conserved recognition mechanism.
Our data provide the first evidence to implicate VAV2 in glucose-induced Rac1 activation, actin remodelling and glucose-stimulated insulin (show INS Antibodies) secretion in pancreatic beta cells.
VAV2 is required for Met signaling in the perinuclear endosome.
Authors propose a model whereby vimentin (show VIM Antibodies) promotes FAK (show PTK2 Antibodies) stabilization through VAV2-mediated Rac1 activation. This model may explain why vimentin (show VIM Antibodies) expressing metastatic lung cancer cells are more motile and invasive.
reduction of VAV2 in absence of CUX1 (show CUX1 Antibodies) was associated with a significant decrease of RAC1 activity in response to epithelial wounding. Our results identify a novel pathway by which CUX1 (show CUX1 Antibodies) regulates normal intestinal epithelial cell restitution
This inhibitory action of Vav2 shRNA on Hcys-induced podocyte injury was associated with reduction of Rac1 activity and ROS (show ROS1 Antibodies) production. These results suggest that elevated Hcys levels activate Vav2 and thereby increase NOX activity leading to ROS (show ROS1 Antibodies) production, which triggers NLRP3 (show NLRP3 Antibodies) inflammasome activation, podocyte dysfunction and glomerular injury.
Results show that Vav2 and Rac1 are commonly involved in blood pressure regulation.
Data demonstrate that the co-expression of the exchange factors Vav2 and Vav3 (show VAV3 Antibodies) is critical for the development of this tumor type.
Vav2 and Vav3 (show VAV3 Antibodies) are required for normal peripheral nerve degeneration/regeneration, revascularization and functional recovery.
The results indicate that ADIP (show SSX2IP Antibodies) plays an essential role in PDGF (show PDGFA Antibodies)-induced cell movement by interacting with afadin (show MLLT4 Antibodies) and Vav2 and regulating the activation of Rac (show AKT1 Antibodies).
CD36 (show CD36 Antibodies) contributes to activation of Vav-1 (show VAV1 Antibodies), -2, and -3 in aortae from hyperlipidemic mice
Cbl (show CBL Antibodies) ubiquitin ligase (show RNF123 Antibodies) plays a critical role in the maintenance of AJs and suppression of cell migration through down-regulation of EGFR (show EGFR Antibodies)-Vav2 signaling.
Data show that Vav2/Vav3 (show VAV3 Antibodies)-deficient mice show early onset of iridocorneal angle changes and elevated intraocular pressure, with subsequent selective loss of retinal ganglion cells and optic nerve head cupping, which are the hallmarks of glaucoma.
Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
guanine nucleotide exchange factor VAV2
, vav 2 oncogene
, Vav2 oncogene