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Our results indicate a possible contribution of CNVs in LEPR (show LEPR Proteins), NEGR1, ARHGEF4 (show ARHGEF4 Proteins), and CPXCR1 (show CPXCR1 Proteins) and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d to the development of obesity, particularly abdominal obesity in Mexican children.
NEGR1, strong candidate gene, associated with clinical features of Depression (e.g., earlier age at onset and recurrent and more severe forms of Depression). Gene expression patterns in the prefrontal and anterior cingulate cortex most closely matched the genetic findings.
Single nucleotide polymorphism in NEGR1 gene is associated with major depressive disorder.
Significant associations were identified at 3.5 years old for TMEM18 (show TMM18 Proteins) rs6548238, NEGR1 rs2815752, BDNF (show BDNF Proteins) rs10767664 and rs6265 (1 year old and 3.5 years old) with anthropometric phenotypes
NEGR1 interacts with NPC2 (show NPC2 Proteins) and increases its protein stability; it has a role in obesity
We observed novel selection signals in CDKAL1 (show CDKAL1 Proteins) and NEGR1, well-known diabetes and obesity susceptibility genes
NEGR1 could be an important locus influencing certain personality dimensions in BN patients.
First study to find an association between an obesity risk gene and differences in white matter integrity. As our subjects were young and healthy, our results suggest that NEGR1 has effects on brain structure independent of its effect on obesity.
Data indicate strong associations with severe obesity for single nucleotide polymorphism (SNP) rs9939609 within the FTO (show FTO Proteins) gene and SNP rs2815752 near the NEGR1 gene.
Results imply a regulatory role for TMEM18 (show TMM18 Proteins), BDNF (show BDNF Proteins), MTCH2 (show MTCH2 Proteins) and NEGR1 in adipocyte differentiation and biology. In addition, we show a variation of MAF (show MAF Proteins) expression during adipogenesis, while NPC1 (show NPC1 Proteins), PTER (show PTER Proteins) and SH2B1 (show SH2B1 Proteins) were not regulated.
The long non-coding RNA, BC048612, and microRNA-203 were determined to be positive and negative regulators of Negr1 gene expression respectively.
Negr1 controls the development of neurite arborization in vitro and in vivo.
a role of NEGR1 in the control of body weight and food intake
These results suggest a function for neurotractin/kilon as a trans-neural growth-promoting factor for outgrowing axons following hippocampal denervation.
glycosylphosphatidylinositol-anchored cell adhesion protein
neuronal growth regulator 1
, neuronal growth regulator 1-like
, IgLON family member 4
, a kindred of IgLON
, kindred of IgLON
, kilon protein