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The findings of the work indicate a role for Galphaq (show GNAQ Proteins) and/or Galpha14 and in CCR2a/CCR2b (show CCR2 Proteins)-stimulated Rho A (show RHOA Proteins) GTPase (show RACGAP1 Proteins)-mediated serum response factor activation.
findings identify GNA14 mutations as a cause of childhood vascular tumors, offer insight into mechanisms of oncogenic transformation by mutations affecting Gaq family members, and identify potential targets for therapeutic intervention
TNF-alpha (show TNF Proteins)/TNFR1 (show TNFRSF1A Proteins) signaling promotes gastric tumorigenesis through induction of Noxo1 (show NOXO1 Proteins) and Gna14 in tumor cells.
TPR1 is required for Galpha14 to stimulate Ras-dependent signaling pathways, but not for the propagation of signals along Ras-independent pathways.
activation of the IKK/NFkappaB signaling cascade by SSTR2 requires a complicated network consisting of Galpha(14), protein kinase C, CamkII, ERK, and c-Src
G14alpha and G16alpha are palmitoylated at distinct polycysteine sequences, and that the adjacent polybasic domain is not required for Galpha (show SUCLG1 Proteins) palmitoylation but is important for localization and functional activity of heterotrimeric G proteins
The ability of CCR1 to signal through Galpha (show SUCLG1 Proteins)(14/16) thus provides a linkage for chemokines to regulate NF-kappaB (show NFKB1 Proteins)-dependent responses.
The phylogenetic trees reveal that porcine Gna14, is evolutionarily close to the human homolog.
This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.
, guanine nucleotide binding protein (G protein), alpha 14
, guanine nucleotide binding protein (G protein), alpha 14 b
, guanine nucleotide-binding protein subunit alpha-14-like
, G-protein subunit alpha-14
, g alpha-14
, guanine nucleotide-binding protein 14
, guanine nucleotide-binding protein subunit alpha-14
, G-protein subunit GL1 alpha
, G protein alpha subunit 14
, guanine nucleotide binding protein (G protein), alpha 14 a
, TGFB inducible early growth response 3