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GNAZ mutations are associated with melanoma.
cGMP-phosphodiesterase 6 can be activated by another cancer-retina antigen, transducin (show GNAT1 Proteins), through Wnt5a (show WNT5A Proteins)-Frizzled-2 (show FZD2 Proteins) cascade, which leads to a lowering of cGMP and an increase in intracellular calcium mobilization.
findings suggest that Galphaz signals may attenuate Rho-induced stimulation of SRF-mediated transcription
present study suggest that Gnaz links the circadian clockwork-via dopamine acting on D4 receptors-to G protein-mediated signaling in intact but not diabetic retina
a novel role of Galpha (show SUCLG1 Proteins)(z) in restraining myogenic differentiation through the disruption of Rho signaling
activation attenuates Rap1-mediated differentiation of PC12 cells.
The active form of Galpha (show SUCLG1 Proteins)(z), but not Galpha (show SUCLG1 Proteins)(i2), is crucial for maintenance of the structure of the Golgi apparatus
Galpha (show SUCLG1 Proteins)(z) knock-out mice display high levels of anxiety-like behaviour and are less sensitive to the action of 8-OH-DPAT. Balb/c mice show much more clear effects of the Galpha (show SUCLG1 Proteins)(z) knock-out than C57Bl/6 mice.
The Gnaz protein exert a negative control on Src (show SRC Proteins) function reducing the activating influence of Receptors, Opioid, mu on this tyrosine kinase (show TYRO3 Proteins) in neural cells.
The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids.
g(x) alpha chain
, guanine nucleotide-binding protein G(z) subunit alpha
, transducin alpha
, Guanine nucleotide binding protein alpha
, guanine nucleotide binding protein, alpha z polypeptide
, guanine nucleotide binding protein, alpha z subunit