B4GALT7 Proteins

Protein Summary

This gene is a member of the beta-1,4-galactosyltransferase (beta4GalT) family. Family members encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. Each beta4GalT member has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus which then remains uncleaved to function as a transmembrane anchor. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein linkage (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) found in proteoglycans. This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located in cis-Golgi instead of trans-Golgi. Mutations in this gene have been associated with the progeroid form of Ehlers-Danlos syndrome.

Alternative names and synonyms associated with B4GALT7

• beta-1,4-galactosyltransferase 7 (B4galt7) antibody
• beta-1,4-galactosyltransferase 7 (B4GALT7) antibody
• xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) (B4galt7) antibody

• B4GAL-T7 antibody
• EDSP1 antibody
• XGALT1 antibody
• XGPT1 antibody

Protein level used designations for B4GALT7

beta-1,4-galactosyltransferase 7 , xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) , xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) , UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7 , UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7 , beta-1,4-GalTase 7 , beta-1,4-galactosyltransferase VII , beta4Gal-T7 , beta4GalT-VII , galactosyltransferase I , proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I , b4Gal-T7